My research focuses on advancing cutting-edge neurophotonics and translational biophotonics technologies that seamlessly connect engineering with fundamental research and medical applications. This interdisciplinary research and training program involves the vertical integration of various fields, such as optics, electrical engineering, micro-nano technology, biology, and clinical medicine. The overarching objective of our work is to enhance our ability to detect diseases at early and manageable stages, monitor the effectiveness of treatments, and guide interventions. These technologies also open new avenues for fundamental research, exploring new territories of disease mechanisms, brain function, biomarker discovery, and integrated diagnosis and therapy (theranostics). Specific areas of interest include:
- Optical Coherence Tomography
- Two-photon Fiberscopy/Endomicroscopy
- Multimodal Imaging
- Mass Spectrometry Imaging
- AI-assisted Image Analysis and Acquisition
Disease Diagnosis & Intervention Guidance
- Label-free and Noninvasive Optical Histology in vivo
- Intra-operative Guidance
- GI Tract (dysplasia and inflammation)
- Airway (cancer and COPD)
- Pre-term Birth Risk Assessment
- Functional Brain Imaging in Freely-behaving Animals
- PhD, Physics and Biomedical Optics, University of Pennsylvania, 1998
- BS, Physics, University of Science and Technology of China, 1990
March 10, 2021Two researchers with ties to Hopkins BME earn grants through Bisciotti Foundation Translational FundTwo Johns Hopkins professors with ties to the Department of Biomedical Engineering have received grants for their research through the Bisciotti Foundation Translational Fund.
February 8, 2018Johns Hopkins researchers report they have developed two new endoscopic probes that significantly sharpen the technology’s imaging resolution and permit direct observation of fine tissue structures and cell activity in small organs in sheep, rats, and mice.
December 20, 2017Patients with chronic acid reflux and other esophageal issues run an increased risk of cancer. A fiber-optic endomicroscope developed from research done by Xingde Li is likely to significantly improve diagnosis and treatment.
One of our group’s projects was selected as a top research highlight in 2015 (beginning at 2:22).