Xingde Li, PhD

Research Interests

My research interest centers on development of cutting-edge and translational biophotonics technologies that interface and bridge basic engineering research and medical diagnosis and intervention. The research and training involves vertical integration of multiple disciplines, including (but not limited to) optics, electrical engineering, micro-nano technology, biology and clinical medicine. The ultimate goal of our research is to transform our capability of disease detection at early, manageable stages, monitoring therapeutic effects and treatment outcomes, and guiding interventions. The technologies also offer new opportunities for basic research in exploring new frontiers of disease mechanisms, brain function, bio-marker discovery and integrated diagnosis and therapy. Some specific research interests include:

• Optical Coherence Tomography (OCT)
• Multiphoton Endomicroscopy
• Label-free Mass-spectrometry Imaging (MSI)
• NIR Fluorescence Imaging
• Functional Nanocapsules and Nanoparticles for Molecular Imaging
• Noninvasive Cancer Detection, Infection and Inflammation Detection, Preterm Birth Assessment, Wound Healing Imaging and Surgical Guidance
• In vivo Cellular Metabolism Imaging, Brain Function Imaging

Titles

• Professor, Biomedical Engineering
• Professor, Electrical & Computer Engineering
• Professor, Oncology

Affiliated Centers & Institutes

• Carnegie Center for Surgical Innovation
• Kavli Neuroscience Discovery Institute

Education

• PhD, Physics and Biomedical Optics, University of Pennsylvania, 1998
• BS, Physics, University of Science and Technology of China, 1990

Recent Highlights

April 28, 2022

From Blurry to Bright: AI Tech Helps Researchers Peer into the Brains of Mice

Johns Hopkins biomedical engineers have developed an artificial intelligence (AI) training strategy to capture images of mouse brain cells in...

• March 10, 2021
  Two researchers with ties to Hopkins BME earn grants through Bisciotti Foundation Translational Fund
  Two Johns Hopkins professors with ties to the Department of Biomedical Engineering have received grants for their research through the Bisciotti Foundation Translational Fund.
• February 8, 2018
  Lights, camera, action! New endomicroscopic probes visualize living animal cell activity
  Johns Hopkins researchers report they have developed two new endoscopic probes that significantly sharpen the technology’s imaging resolution and permit direct observation of fine tissue structures and cell activity in small organs in sheep, rats, and mice.
• December 20, 2017
  Upstarts: For Heartburn…And More
  Patients with chronic acid reflux and other esophageal issues run an increased risk of cancer. A fiber-optic endomicroscope developed from research done by Xingde Li is likely to significantly improve diagnosis and treatment.

Media

One of our group’s projects was selected as a top research highlight in 2015 (beginning at 2:22).