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Xingde Li, PhD

Xingde Li
Research Focus Area(s): Imaging and Medical Devices, Neuroengineering
Research Interests: Medical imaging and biophotonics
Research Interests

Research Interests

My research interest centers on development of cutting-edge and translational biophotonics technologies that interface and bridge basic engineering research and medical diagnosis and intervention. The research and training involves vertical integration of multiple disciplines, including (but not limited to) optics, electrical engineering, micro-nano technology, biology and clinical medicine. The ultimate goal of our research is to transform our capability of disease detection at early, manageable stages, monitoring therapeutic effects and treatment outcomes, and guiding interventions. The technologies also offer new opportunities for basic research in exploring new frontiers of disease mechanisms, brain function, bio-marker discovery and integrated diagnosis and therapy. Some specific research interests include:

  • Optical Coherence Tomography (OCT)
  • Multiphoton Endomicroscopy
  • Label-free Mass-spectrometry Imaging (MSI)
  • NIR Fluorescence Imaging
  • Functional Nanocapsules and Nanoparticles for Molecular Imaging
  • Noninvasive Cancer Detection, Infection and Inflammation Detection, Preterm Birth Assessment, Wound Healing Imaging and Surgical Guidance
  • In vivo Cellular Metabolism Imaging, Brain Function Imaging
Titles & Affiliations


  • Professor, Biomedical Engineering
  • Professor, Electrical & Computer Engineering
  • Professor, Oncology

Affiliated Centers & Institutes



  • PhD, Physics and Biomedical Optics, University of Pennsylvania, 1998
  • BS, Physics, University of Science and Technology of China, 1990
Faculty News

Recent Highlights

  • February 8, 2018
    Johns Hopkins researchers report they have developed two new endoscopic probes that significantly sharpen the technology’s imaging resolution and permit direct observation of fine tissue structures and cell activity in small organs in sheep, rats, and mice.
  • December 20, 2017
    Patients with chronic acid reflux and other esophageal issues run an increased risk of cancer. A fiber-optic endomicroscope developed from research done by Xingde Li is likely to significantly improve diagnosis and treatment.
  • November 20, 2014
    With a single scanning optical fiber, biomedical engineering Professor Xingde Li and his team are creating label-free and processing-free microscopes that go where no others can.


One of our group’s projects was selected as a top research highlight in 2015 (beginning at 2:22).

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