Skip to Content

Xingde Li, PhD

Xingde Li
Research Interests: Medical imaging and devices, neurophotonics and translational biophotonics
Research Interests

Research Interests

My research focuses on advancing cutting-edge neurophotonics and translational biophotonics technologies that seamlessly connect engineering with fundamental research and medical applications. This interdisciplinary research and training program involves the vertical integration of various fields, such as optics, electrical engineering, micro-nano technology, biology, and clinical medicine. The overarching objective of our work is to enhance our ability to detect diseases at early and manageable stages, monitor the effectiveness of treatments, and guide interventions. These technologies also open new avenues for fundamental research, exploring new territories of disease mechanisms, brain function, biomarker discovery, and integrated diagnosis and therapy (theranostics). Specific areas of interest include:


  • Optical Coherence Tomography
  • Two-photon Fiberscopy/Endomicroscopy
  • Multimodal Imaging
  • Mass Spectrometry Imaging
  • AI-assisted Image Analysis and Acquisition

Disease Diagnosis & Intervention Guidance

  • Label-free and Noninvasive Optical Histology in vivo
  • Intra-operative Guidance
  • GI Tract (dysplasia and inflammation)
  • Airway (cancer and COPD)
  • Pre-term Birth Risk Assessment

Basic Research

  • Functional Brain Imaging in Freely-behaving Animals
Titles & Affiliations


  • Professor, Biomedical Engineering
  • Professor, Electrical & Computer Engineering
  • Professor, Oncology

Affiliated Centers & Institutes



  • PhD, Physics and Biomedical Optics, University of Pennsylvania, 1998
  • BS, Physics, University of Science and Technology of China, 1990
Faculty News

Recent Highlights



One of our group’s projects was selected as a top research highlight in 2015 (beginning at 2:22).

Read the Johns Hopkins University privacy statement here.