Skip to Content

Two researchers with ties to Hopkins BME earn grants through Bisciotti Foundation Translational Fund

March 10, 2021
Xingde Li and Alan Cohen

Two Johns Hopkins professors with ties to the Department of Biomedical Engineering have received grants for their research through the Bisciotti Foundation Translational Fund.

Established with a generous multiyear gift from the Stephen and Renee Bisciotti Foundation, the fund provides $300,000 annually in seed money to advance Johns Hopkins discoveries on a commercial path. Recipients are awarded from $25,000 and $100,000 to conduct their work during a period of up to nine months.

For this year’s funding round, 26 applications were submitted. Six finalists presented their work in late January to an outside panel of researchers, other scientists and investors.

Each applicant has made a report of invention to Johns Hopkins Technology Ventures (JHTV).

“This was a unique year with four recipients,” says Brian Stansky, senior director of FastForward, JHTV’s startup program. “Thanks to the generosity of the Bisciotti Foundation, the investment committee was able to provide funding in leading edge areas such as gene therapy, optical histology, advanced surgical procedures and neurosurgery. We look forward to working with the faculty members on both their funded projects and longer-term commercialization efforts.

The following researchers and their projects associated with BME have received the Bisciotti Foundation Translation Fund grants.

Fiber-Optic Multiphoton Endomicroscopy Capable of Noninvasive “Optical Histology” for Basic Research Use and Clinical Translation

Principal investigator: Xingde Li, professor of biomedical engineering with joint appointments in the Johns Hopkins Kimmel Cancer Center and the Department of Electrical and Computer Engineering at The Johns Hopkins University.

The pitch: A flexible and ultra-compact imaging system to view living biological tissues at histology resolution.

Multiphoton fluorescence (MPF) imaging provides structural, molecular and biomechanical information about biological tissues at a subcellular level. Benchtop multiphoton microscopes have become indispensable research tools in cell biology and neuroscience, but the microscopes’ size makes it difficult to image live animals, particularly free-behaving ones.

Li and his colleagues have created a compact, flexible, lightweight and portable MPF imaging system that can be placed atop rodents for functional brain imaging and can be used to perform “optical histology,” meaning tissue does not need to be removed from the body for analysis. The researchers have developed and customized the system so that the imaging quality is comparable to that of a benchtop multiphoton microscope, but at a fraction of the cost.

Li and co-principal investigator Hyeon-cheol Park have developed a prototype and will use the Bisciotti funding to prepare for commercialization, including standardizing the engineering protocol, refining the technology and testing for safety. Johns Hopkins Technology Ventures obtained patent protection for the technology, which also is available for licensing. Li plans to launch a startup company and has already attracted industry interest.

CortiTech: Atraumatic Brain Retractor for Minimally Invasive Neurosurgery

Principal investigator: Alan Cohen, director of Johns Hopkins pediatric neurosurgery and professor, Department of Neurosurgery

The pitch: A safer and easier way to operate on brain tumors

Surgical excision is the gold standard for treating tumors and blood clots deep in the brain. But retraction — holding apart brain tissue to enable access to a tumor — can cause brain bleeding, swelling or bruising, leading to loss of motor control, vision and speech. The size of most retractions is set prior to surgery, meaning doctors cannot adjust during the procedure.

Cohen developed Radiex, which uses an expanding “smart balloon” at the tip of a thin, rigid catheter to retract brain tissue. The shunt-sized device makes a minimally invasive insertion into the brain to reach the tumor, at which point the balloon can expand as needed to push the brain away from the operating area. Tests on simulated brain hydrogels and pig cadavers showed Radiex causes at least 40% less pressure on the brain compared to established retractors.

Students from Johns Hopkins Biomedical Engineering, led by Sun Jay Yoo and under the direction of Amir Manbachi, have assisted Cohen’s work on Radiex. Yoo has become the CEO of CortiTech, which licensed the technology, and Cohen is clinical lead on the company’s advisory board. The company plans to use the funding for technology validation and clinical partnership establishment as it moves toward commercialization.

Johns Hopkins Technology Ventures is pursuing patent protection for the technology.

Sung Hoon Kang, assistant professor in the Department of Mechanical Engineering, and Vivek Kumbhari, associate professor in the Department of Gastroenterology and Hepatology, have also been named recipients.

Read the full article at Johns Hopkins Technology Ventures.

Category: Research
Associated Faculty: Xingde Li

Read the Johns Hopkins University privacy statement here.