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Leslie Tung, PhD

Professor
Les Tung
Research Focus Area(s): Translational Cell and Tissue Engineering
Research Interests: Electrophysiology and arrhythmia of cardiac cell networks, cardiac tissue engineering, stem cell-derived heart cells, cardiac disease models
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Research Interests

Research Interests

Engineering the Heart in a Dish

Our research involves the study of functional properties of engineered networks of living cardiac cells at varying structural levels that include single cells, cell strands, 2D sheets, and 3D tissue. We culture neonatal rat ventricular cells, human embyonic stem cell-derived cardiomyocytes and human induced pluripotent stem cell-derived cardiomyocytes as multicellular networks to investigate fundamental properties of action potential propagation and arrhythmias. The use of voltage-sensitive dyes and optical mapping allows us to follow the temporal and spatial patterns of electrical activity.

Our work is currently directed within the following areas:

  • Functional properties of cardiomyocytes derived from human pluripotent stem cells
  • Engineered cardiac tissues
  • High frequency alternating current for cardiac therapy
  • Myofibroblast-cardiomyocyte interactions More details are available on our lab website.
Titles & Affiliations

Titles

  • Professor, Biomedical Engineering
  • Director, Academic Success via Postdoctoral Independence in Research and Education (ASPIRE)

Affiliated Centers & Institutes

Education

Education

  • PhD, Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 1978
  • MS, Electrical Engineering, Massachusetts Institute of Technology, 1972
  • BS, Electrical Engineering, Massachusetts Institute of Technology, 1972

 

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