Engineering the Heart in a Dish
Our research involves the study of functional properties of engineered networks of living cardiac cells at varying structural levels that include single cells, cell strands, 2D sheets, and 3D tissue. We culture neonatal rat ventricular cells, human embyonic stem cell-derived cardiomyocytes and human induced pluripotent stem cell-derived cardiomyocytes as multicellular networks to investigate fundamental properties of action potential propagation and arrhythmias. The use of voltage-sensitive dyes and optical mapping allows us to follow the temporal and spatial patterns of electrical activity.
Our work is currently directed within the following areas:
- Functional properties of cardiomyocytes derived from human pluripotent stem cells
- Engineered cardiac tissues
- High frequency alternating current for cardiac therapy
- Myofibroblast-cardiomyocyte interactions More details are available on our lab website.
- PhD, Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 1978
- MS, Electrical Engineering, Massachusetts Institute of Technology, 1972
- BS, Electrical Engineering, Massachusetts Institute of Technology, 1972
March 20, 2017Six members of the Department of Biomedical Engineering at Johns Hopkins University have been elected to the College of Fellows at the American Institute for Medical and Biological Engineering.
June 1, 2015Leslie Tung, PhD, professor and director of undergraduate studies in biomedical engineering, has been named interim director of the department of biomedical engineering.
April 20, 2015By using a two-step electrical pulse, researchers Les Tung and Ron Berger found that the first “kinder, gentler” surge, preconditions the skeletal muscles for the second larger pulse.