Xiaofeng Jia, MD, PhD

Research Interests

Dr. Jia’s research interests include brain monitoring and therapeutic hypothermia, brain recovery after cardiac arrest, peripheral nerve injury and regeneration, the translational therapeutic model for neurological injuries, and the development and characterization of biomaterials for peripheral nerve and bone regeneration.

1. Brain Recovery after Cardiac Arrest
   • This project will develop and optimize a novel glycan-based intervention via metabolic glycoengineering to promote neural stem cell interaction in vitro, and to improve neurological outcomes after cardiac arrest. It will track the fate of transplanted neural stem cells and explore related mechanisms with improved cell survival. We also focus on the development of novel translational tools for uncovering mechanisms of brain injury after cardiac arrest, monitoring and tracking neurological injuries, and guiding treatments like therapeutic hypothermia.
2. Peripheral Nerve Injury and regeneration
   • This project will enhance adipose stem cell adhesion and differentiation in vitro via stem cell surface modification, and improve nerve regeneration after critical-sized nerve repair with sugar analog treated adipose stem cells. Our lab will also investigate the effect of NCSC derived exosome therapy in peripheral nerve crush injury and nerve defect repair animal models.
3. Spinal cord injury
   • We aim to explore pathological mechanisms of spinal cord injury, monitor and track neurological injuries, and develop novel therapeutic methods to promote neuroregeneration and neuroprotection.

Titles

• Adjunct Professor, Biomedical Engineering, Johns Hopkins University
• Professor, Neurosurgery, University of Maryland School of Medicine

Education

• Post-doctoral fellow, Biomedical Engineering, Johns Hopkins University, 2004-2007
• PhD, Surgery (Orthopaedics), Fudan University, 2003
• MS, Surgery, Shanghai Medical University, 1997
• MD, Clinical Medicine, Zhejiang Medical University, 1994