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Jamie Spangler, PhD

Jamie Spangler
Research Interests: Structural and molecular immunology, protein engineering, therapeutic antibody discovery and design, targeted drug development
Lab Website: Spangler Lab
Research Interests

Research Interests

Jamie Spangler’s research aims to expand the repertoire of protein therapeutics by redesigning naturally occurring proteins and engineering new molecules to overcome the deficiencies of existing drugs. Integrating cutting-edge tools from structural biophysics, biomolecular engineering, and translational immunology, her research focuses on developing innovative platforms for the discovery and design of proteins that recruit novel mechanisms for disease therapy. In particular, Spangler’s group is interested in engineering antibody-based molecules that reshape immune cell behavior for targeted treatment of cancer, infectious diseases, and autoimmune disorders. The overarching goal of her interdisciplinary research program is to establish new insights into protein behavior and the extent to which it can be manipulated for medically relevant applications.

Titles & Affiliations


  • The William R. Brody Faculty Scholar
  • Associate Professor, Biomedical Engineering
  • Associate Professor, Chemical & Biomolecular Engineering
  • Associate Professor, Oncology

Affiliated Centers & Institutes



  • PhD, Biological Engineering, Massachusetts Institute of Technology, 2011
  • BS, Biomedical Engineering, Johns Hopkins University, 2006
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