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Jamie Spangler, PhD

The William R. Brody Faculty Scholar, Assistant Professor
Jamie Spangler
Research Focus Area(s): Genomics and Systems Biology, Immunoengineering, Translational Cell and Tissue Engineering
Research Interests: Structural and molecular immunology, protein engineering, therapeutic antibody discovery and design, targeted drug development
Lab Website: Spangler Lab
Research Interests

Research Interests

Jamie Spangler’s research aims to expand the repertoire of protein therapeutics by redesigning naturally occurring proteins and engineering new molecules to overcome the deficiencies of existing drugs. Integrating cutting-edge tools from structural biophysics, biomolecular engineering, and translational immunology, her research focuses on developing innovative platforms for the discovery and design of proteins that recruit novel mechanisms for disease therapy. In particular, Spangler’s group is interested in engineering antibody-based molecules that reshape immune cell behavior for targeted treatment of cancer, infectious diseases, and autoimmune disorders. The overarching goal of her interdisciplinary research program is to establish new insights into protein behavior and the extent to which it can be manipulated for medically relevant applications.

Titles & Affiliations


  • The William R. Brody Faculty Scholar
  • Assistant Professor, Biomedical Engineering
  • Assistant Professor, Chemical & Biomolecular Engineering
  • Assistant Professor, Oncology

Affiliated Centers & Institutes



  • PhD, Biological Engineering, Massachusetts Institute of Technology, 2011
  • BS, Biomedical Engineering, Johns Hopkins University, 2006
Faculty News

Recent Highlights

  • February 15, 2022
    Jamie Spangler, the William R. Brody Faculty Scholar and assistant professor in the departments of Biomedical Engineering and Chemical and Biomolecular Engineering, is a recipient of the National Science Foundation’s Early CAREER Award, which recognizes early stage scholars with high levels of promise and excellence.
  • January 18, 2022
    Jamie Spangler, the William R. Brody Faculty Scholar and assistant professor in the departments of biomedical engineering and chemical and biomolecular engineering, has been awarded a 2022 Damon Runyon-Rachleff Innovation Award by the Damon Runyon Cancer Research Foundation.
  • August 2, 2021
    AbMeta Therapeutics, launched by biologist and Provost Denis Wirtz, bioengineer Jamie Spangler, and clinician Elizabeth Jaffee, will combine years of pioneering research to target metastasis.


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