Research Interests
Jamie Spangler’s research aims to expand the repertoire of protein therapeutics by redesigning naturally occurring proteins and engineering new molecules to overcome the deficiencies of existing drugs. Integrating cutting-edge tools from structural biophysics, biomolecular engineering, and translational immunology, her research focuses on developing innovative platforms for the discovery and design of proteins that recruit novel mechanisms for disease therapy. In particular, Spangler’s group is interested in engineering antibody-based molecules that reshape immune cell behavior for targeted treatment of cancer, infectious diseases, and autoimmune disorders. The overarching goal of her interdisciplinary research program is to establish new insights into protein behavior and the extent to which it can be manipulated for medically relevant applications.
Titles
- The William R. Brody Faculty Scholar
- Associate Professor, Biomedical Engineering
- Associate Professor, Chemical & Biomolecular Engineering
- Associate Professor, Oncology
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Associate Professor, Ophthalmology
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Associate Professor, Molecular Microbiology & Immunology
Affiliated Centers & Institutes
Education
- PhD, Biological Engineering, Massachusetts Institute of Technology, 2011
- BS, Biomedical Engineering, Johns Hopkins University, 2006
Recent Highlights
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December 15, 2025Spangler was delightfully surprised with $300,000 in research funding for her groundbreaking work in molecular immunoengineering.
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June 23, 2025The Discovery Awards are intended to spark new interactions among investigators across the university rather than to support established projects.
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April 3, 2025A pioneering investigator in protein engineering, Spangler was recognized for her work designing new technologies to interrogate and manipulate the immune system at the protein level.