Jamie Spangler’s research aims to expand the repertoire of protein therapeutics by redesigning naturally occurring proteins and engineering new molecules to overcome the deficiencies of existing drugs. Integrating cutting-edge tools from structural biophysics, biomolecular engineering, and translational immunology, her research focuses on developing innovative platforms for the discovery and design of proteins that recruit novel mechanisms for disease therapy. In particular, Spangler’s group is interested in engineering antibody-based molecules that reshape immune cell behavior for targeted treatment of cancer, infectious diseases, and autoimmune disorders. The overarching goal of her interdisciplinary research program is to establish new insights into protein behavior and the extent to which it can be manipulated for medically relevant applications.
- The William R. Brody Faculty Scholar
- Assistant Professor, Biomedical Engineering
- Assistant Professor, Chemical & Biomolecular Engineering
- Assistant Professor, Oncology
Affiliated Centers & Institutes
- PhD, Biological Engineering, Massachusetts Institute of Technology, 2011
- BS, Biomedical Engineering, Johns Hopkins University, 2006
February 21, 2024Spangler is the recipient of a 2024 Damon Runyon-Rachleff Innovation Award to continue a multi-year project aimed at developing new immunotherapy approaches.
September 26, 2023Funding from the Advanced Research Projects Agency for Health (ARPA-H) will fast-track the development of new cancer implant technology.
September 18, 2023Breakthrough research from Jamie Spangler, an assistant professor of chemical and biomolecular engineering and biomedical engineering, has potential implications for treatment of injuries.