Jamie Spangler’s research aims to expand the repertoire of protein therapeutics by redesigning naturally occurring proteins and engineering new molecules to overcome the deficiencies of existing drugs. Integrating cutting-edge tools from structural biophysics, biomolecular engineering, and translational immunology, her research focuses on developing innovative platforms for the discovery and design of proteins that recruit novel mechanisms for disease therapy. In particular, Spangler’s group is interested in engineering antibody-based molecules that reshape immune cell behavior for targeted treatment of cancer, infectious diseases, and autoimmune disorders. The overarching goal of her interdisciplinary research program is to establish new insights into protein behavior and the extent to which it can be manipulated for medically relevant applications.
- Assistant Professor, Biomedical Engineering
- Assistant Professor, Chemical & Biomolecular Engineering
- Assistant Professor, Oncology
Affiliated Centers & Institutes
- PhD, Biological Engineering, Massachusetts Institute of Technology, 2011
- BS, Biomedical Engineering, Johns Hopkins University, 2006
September 28, 2020Johns Hopkins researchers develop system for using everyday glucose monitors to detect COVID-19 antibodiesA trio of Johns Hopkins scientists—a pharmacologist, a biomedical engineer, and a biophysicist—are pooling their knowledge to design a device that can detect whether a person has antibodies linked to SARS-CoV-2, the virus that causes COVID-19.
June 18, 2020Jamie Spangler, assistant professor of biomedical engineering and chemical and biomolecular engineering, is among the thirty-six early-career faculty members selected to receive a 2020 Johns Hopkins Catalyst Award.
February 28, 2020Jamie Spangler, assistant professor in the Department of Biomedical Engineering and the Department of Chemical and Biomolecular Engineering, is among three faculty from Johns Hopkins to receive a grant through the Bisciotti Foundation Translational Fund.