Jamie Spangler’s research aims to expand the repertoire of protein therapeutics by redesigning naturally occurring proteins and engineering new molecules to overcome the deficiencies of existing drugs. Integrating cutting-edge tools from structural biophysics, biomolecular engineering, and translational immunology, her research focuses on developing innovative platforms for the discovery and design of proteins that recruit novel mechanisms for disease therapy. In particular, Spangler’s group is interested in engineering antibody-based molecules that reshape immune cell behavior for targeted treatment of cancer, infectious diseases, and autoimmune disorders. The overarching goal of her interdisciplinary research program is to establish new insights into protein behavior and the extent to which it can be manipulated for medically relevant applications.
- The William R. Brody Faculty Scholar
- Assistant Professor, Biomedical Engineering
- Assistant Professor, Chemical & Biomolecular Engineering
- Assistant Professor, Oncology
Affiliated Centers & Institutes
- PhD, Biological Engineering, Massachusetts Institute of Technology, 2011
- BS, Biomedical Engineering, Johns Hopkins University, 2006
July 17, 2023A Johns Hopkins Medicine team suggests that microparticle-delivered therapy may be the first step toward stopping MS and other autoimmune diseases.
October 21, 2022Researchers design a protein that can activate and increase the number of specialized cells that can prevent the onset of autoimmune disorders.
May 12, 2022Jamie Spangler, the William R. Brody Faculty Scholar and assistant professor in the departments of Biomedical Engineering and Chemical and...