Research Interests
Jamie Spangler’s research aims to expand the repertoire of protein therapeutics by redesigning naturally occurring proteins and engineering new molecules to overcome the deficiencies of existing drugs. Integrating cutting-edge tools from structural biophysics, biomolecular engineering, and translational immunology, her research focuses on developing innovative platforms for the discovery and design of proteins that recruit novel mechanisms for disease therapy. In particular, Spangler’s group is interested in engineering antibody-based molecules that reshape immune cell behavior for targeted treatment of cancer, infectious diseases, and autoimmune disorders. The overarching goal of her interdisciplinary research program is to establish new insights into protein behavior and the extent to which it can be manipulated for medically relevant applications.
Titles
- The William R. Brody Faculty Scholar
- Associate Professor, Biomedical Engineering
- Associate Professor, Chemical & Biomolecular Engineering
- Associate Professor, Oncology
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Associate Professor, Ophthalmology
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Associate Professor, Molecular Microbiology & Immunology
Affiliated Centers & Institutes
Education
- PhD, Biological Engineering, Massachusetts Institute of Technology, 2011
- BS, Biomedical Engineering, Johns Hopkins University, 2006
Recent Highlights
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February 20, 2025Biomedical engineer Jamie Spangler and her team at Johns Hopkins develop innovative treatments for autoimmune disorders, cancer, and other complex diseases.
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September 25, 2024Immunoengineering research by Johns Hopkins biomedical engineers was recently featured on the cover of the journal JCI Insight.
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May 29, 2024Jamie Spangler, associate professor of biomedical engineering, has earned a Melanoma Research Alliance Pilot Award for her work titled "Immunotherapeutic cytokine/antibody fusion protein to treat acral melanoma."