Welcome to the Doloff Lab for Immunoengineering and Regenerative Medicine. Our mission is to explore the intersection between therapeutics, whether biologic or synthetic in origin, and living systems to better understand what happens when deliverables are introduced into the body and how the host immune system behaves as well as perceives them.
Joshua C. Doloff is a newly appointed Assistant Professor in Biomedical Engineering and Materials Science and Engineering at Johns Hopkins University’s School of Medicine. He was previously a Juvenile Diabetes Research Foundation (JDRF) Senior Postdoctoral Fellow in the labs of Robert Langer and Daniel G. Anderson in Chemical Engineering and the David H. Koch Institute at MIT/Children’s Hospital Boston.
- Farah S, Doloff JC, Mueller P, Sadraei A, Han HJ, Olafson K, Tyas K, Tam HH, Hollister-Locke J, Griffin M, Meng A, McGarrigle J, Greiner DL, Weir G, Oberholzer J, Langer R, and Anderson DG. 2018. Long-Term Implant Fibrosis Prevention in Rodents and Non-Human Primates Using Crystallized Drug Formulations (accepted in press, Nature Materials).
- Bochenek MA, Veiseh O, Vegas AJ, McGarrigle JJ, Qi M, Marchese E, Omami M, Doloff JC, Mendoza-Elias J, Nourmohammadzadeh M, Khan A, Yeh C, Isa D, Ghani S, Li J, Landry C, Bader AR, Olejnik K, Chen M, Hollister-Lock J, Wang Y, Greiner DL, Weir GC, Strand BL, Rokstad AM, Lacik I, Langer R, Anderson DG, and Oberholzer J. 2018. Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques. Nature Biomedical Engineering. 2018 Aug 13.
- Xie X, Doloff JC, Yesilyurt V, Sadraei A, McGarrigle J, Omami M, Veiseh O, Isa D, Ghani S, Joshi I, Li J, Wang W, Tam HH, Tao J, Chen H, Yang B, Oberholzer J, Langer RS, Anderson DG. 2018. Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer. Nature Biomedical Engineering. 2018 July 30.
Study points a way to better implants
Selectively blocking immune cells can prevent formation of scar tissue around medical devices.
Medical devices implanted in the body for drug delivery, sensing, or tissue regeneration usually come under fire from the host’s immune system. Defense cells work to isolate material they consider foreign to the body, building up a wall of dense scar tissue around the devices, which eventually become unable to perform their functions.