Complexe biomaterial response to cell encapsulation system with islets inside - blue DAPI, green Macrophages, Red alpha smooth muscle actin (inside green islet clusters)
Complex biomaterial response to cell encapsulation system with islets inside – blue DAPI, green Macrophages, Red alpha smooth muscle actin (inside green islet clusters)

Lab Mission

Welcome to the Doloff Lab for Immunoengineering and Regenerative Medicine. Our mission is to explore the intersection between therapeutics, whether biologic or synthetic in origin, and living systems to better understand what happens when deliverables are introduced into the body and how the host immune system behaves as well as perceives them.

Joshua C Doloff, PhD
Joshua C Doloff, PhD
Doloff Lab

Principal Investigator

Joshua C. Doloff is a newly appointed Assistant Professor in Biomedical Engineering and Materials Science and Engineering at Johns Hopkins University’s School of Medicine. He was previously a Juvenile Diabetes Research Foundation (JDRF) Senior Postdoctoral Fellow in the labs of Robert Langer and Daniel G. Anderson in Chemical Engineering and the David H. Koch Institute at MIT/Children’s Hospital Boston. Full Bio

Faculty Highlight: Meet Joshua Doloff, Assistant Professor of BME

With an interest at the intersection of technology and biology, in this interview, Dr. Doloff describes his eagerness to build research collaborations and provide mentorship to students. He also discusses his “eureka moments,” the research he plans to conduct at Hopkins, and the future of engineering… continue reading

Passion and mentoring are key to the success of the Doloff Lab (JHU News-Letter interview)

As a newly appointed Assistant Professor of Biomedical Engineering and Materials Science at the School of Medicine, Joshua Doloff is not only a research scientist advancing the fields of immunoengineering and regenerative medicine, but also a mentor to students… continue reading

Select Publications

  1. Farah S*, Doloff JC*, Mueller P, Sadraei A, Han HJ, Olafson K, Tyas K, Tam HH, Hollister-Locke J, Griffin M, Meng A, McGarrigle J, Greiner DL, Weir G, Oberholzer J, Langer R, and Anderson DG. 2019. Long-Term Implant Fibrosis Prevention in Rodents and Non-Human Primates Using Crystallized Drug Formulations. Nature Materials. Aug;18(8):892-904. doi: 10.1038/s41563-019-0377-5.
  2. Bochenek MA, Veiseh O, Vegas AJ, McGarrigle JJ, Qi M, Marchese E, Omami M, Doloff JC, Mendoza-Elias J, Nourmohammadzadeh M, Khan A, Yeh C, Isa D, Ghani S, Li J, Landry C, Bader AR, Olejnik K, Chen M, Hollister-Lock J, Wang Y, Greiner DL, Weir GC, Strand BL, Rokstad AM, Lacik I, Langer R, Anderson DG, and Oberholzer J. 2018. Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques. Nature Biomedical Engineering. Aug 13. doi: 10.1038/s41551-018-0275-1.
  3. Xie X*, Doloff JC*, Yesilyurt V*, Sadraei A*, McGarrigle J, Omami M, Veiseh O, Isa D, Ghani S, Joshi I, Li J, Wang W, Tam HH, Tao J, Chen H, Yang B, Oberholzer J, Langer RS, Anderson DG. 2018. Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer. Nature Biomedical Engineering. July 30. doi: 10.1038/s41551-018-0273-3.
  4. Doloff JC, Veiseh O, Vegas AJ, Tam HH, Farah S, Ma M, Li J, Bader A, Chiu A, Sadraei A, Aresta-Dasilva S, Griffin M, Jhunjhunwala S, Webber M, Siebert S, Tang K, Chen M, Langan E, Dholokia, Thakrar R, Qi M, Oberholzer J, Greiner DL, Langer R, and Anderson DG. 2017. Colony Stimulating Factor-1 Receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates. Nature Materials. Mar 20. doi: 10.1038/nmat4866.

ALL SELECTED PUBLICATIONS

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Latest News

Drug crystals to prevent medical device fibrosis

Implanted medical devices can save lives, but can also put patients at the risk of fibrosis, a condition in which the immune system attacks the device and produces scar tissue around it, interfering with the device’s functionality. Working with researchers at Massachusetts Institute of Technology, Joshua Doloff, an assistant professor of biomedical engineering at Johns Hopkins University and former MIT postdoc, has devised a new way to prevent fibrosis: loading implantable devices with a crystallized immunosuppressant drug… continue reading

Study points a way to better implants

Medical devices implanted in the body for drug delivery, sensing, or tissue regeneration usually come under fire from the host’s immune system. Defense cells work to isolate material they consider foreign to the body, building up a wall of dense scar tissue around the devices, which eventually become unable to perform their functions… continue reading

Designing better medical implants

A team of researchers has come up with a way to reduce that immune-system rejection. In a study in Nature Materials, they found that the geometry of implantable devices has a significant impact on how well the body will tolerate them… continue reading