Publications

For a full overview visit:

Science Translational Medicine, Jan 2026
Advanced Materials, June 2024
Nature Materials, August 2019
Nature Materials, June 2017
Nature Medicine, March 2016
Nature Materials, June 2015

Selected Publications

(*: co-first; #: co-corresponding)

  1. Bochenek MA*, Farah S*, Doloff JC*, Han HJ, Sadraei A, Jeang WJ, Shaheen-Mualim M, Kuter N, Odeh E, Facklam A, Dinardo A, Engquist E, Rios R, Isa D, Ghani S, Joshi I, Xing Y, Wang Y, Pop R, Greiner DL, Oberholzer J, Langer R, and Anderson DG. Crystallized Colony Stimulating Factor-1 Receptor Inhibitor Protects Immunoisolated Allo but not Xeno Transplants in Primates. Science Translational Medicine. 2026 Jan 28; 18(834):eadt1055. doi: 10.1126/scitranslmed.adt1055.
  2. Steger L, Ghaith AK, Weber-Levine C, Robinson K, Krueger C, Smit C, Krishnan S, Leadingham KMK, Davidar D, Routkevich D, Jiang K, Quiroz V, Bauer S, Liang R, Kerenshy M, Suk I, Tyler B, Doloff JC, Theodore N, Manbachi A. Precision in Spinal Cord Injury Research: A Novel Electromagnetic Impactor for a Consistent Porcine Model. Ann Biomed Eng. 2025 Nov; 53(11):2983-2995. doi: 10.1007/s10439-025-03836-6.
  3. Zhu Y, Yao ZC, Li S, Ma J, Wei C, Yu D, Stelzel JL, Ni BYX, Miao Y, Van Batavia K, Lu X, Lin J, Dai Y, Kong J, Shen R, Goodier KD, Liu X, Cheng L, Vuong I, Howard GP, Livingston NK, Choy J, Schneck JP, Doloff JC, Reddy SK, Hickey JW, Mao HQ. mRNA lipid nanoparticle-incorporated nanofiber-hydrogel composite generates a local immunostimulatory niche for cancer immunotherapy. Nature Communications. 2025 Jul 1; 16(1): 5707. doi: 10.1038/s41467-025-61299-8.
  4. Stelzel JL, Schneck JP, Mao H-Q, Doloff JC. Oversimplified immunology is holding biomaterials back. Nature Reviews Bioengineering. 2025 May 19.
  5. Kong J, Yao ZC, Stelzel JL, Yang YH, Chen J, Feng H, Schmidt C, Zhang C, Krishnan K, Chen L, Pan J, Ding K, Zhu Y, Li X, Doloff JC, Mao HQ, Reddy SK. Granular Nanofiber-Hydrogel Composite-Programmed Regenerative Inflammation and Adipose Tissue Formation. Adv Healthc Mater. 2025 Jan;14(3):e2403094. doi: 10.1002/adhm.202403094. Epub 2024 Nov 24.
  6. Hernandez JL, Daniel J, Stelzel JL, Prasad NR, Soares VV, Doloff JC. Immunologic comparisons of strain and induction method in an improved mouse model of intrauterine fibrosis. bioRxiv [Preprint]. 2024 Nov 3:2024.10.30.621047. doi: 10.1101/2024.10.30.621047.
  7. Schuster CR, Reiche E, Keller PR, Hu S, Soares V, Rahmayanti S, Suresh V, Harris T, Doloff JC, Tuffaha S, and Coon D. Testosterone promotes nerve tethering and acellular biomaterial perineural fibrosis in a rat wound repair model. Advances in Wound Care. 2024. doi: 10.1089/wound.2024.0043.
  8. Reiche E, Keller PR, Soares V, Schuster CR, Rahmayanti S, Mroueh J, Mroueh V, Billaud M, Hu S, Hoover-Watson H, Lian CG, Tan Y, Doloff JC, Newell-Fugate A, and Coon D. Androgenic Steroids Induce Pathologic Scarring in a Preclinical Swine Model Via Dysfunctional Extracellular Matrix Deposition. FASEB. 2024 March 26. doi: 10.1096/fj.202302144RRR.
  9. Livingston NK, Hickey JW, Sim H, Salathe SF, Choy J, Silver A, Kong J, Stelzel J, Omotoso MO, Li S, Chaisawangwong W, Roy S, Bieler J, Est Witte S, Leonard E, Ariail EC, Doloff JC, Spangler J, Mao HQ, and Schneck JP. In Vivo Stimulation of Therapeutic Antigen-Specific T cells in an Artificial Lymph Node Matrix. Advanced Materials. 2024 Feb 15. doi: 10.1002/adma.202310043.
  10. Quiroz VM*, Wang Y*, Rakoski AI, Kasinathan D, Neshat SY, Hollister-Lock J, and Doloff JC. Hydrogel alginate considerations for improved 3D Matrix stability and cell graft viability and function in studying Type 1 Diabetes in vitro. Advanced Biology. 2024 Jan 20:e2300502. doi: 10.1002/adbi.202300502.
  11. Zhu Y, Ma J, Shen R, Lin J, Li S, Lu X, Stelzel J, Kong J, Cheng L, Vuong I, Yao Z-C, Wei C, Korinetz N, Toh WH, Choy J, Reynolds R, Shears M, Cho WJ, Livingston N, Howard G, Hu Y, Tzeng SY, Zack D, Green JJ, Zheng L, Doloff JC, Schneck J, Reddy S, Murphy S, Mao H-Q. Screening for Lipid Nanoparticles that modulate the Immune Activity of helper T cells towards enhanced Antitumour activity. Nature Biomedical Engineering. 2023 Dec 11; doi: 10.1038/s41551-023-01131-0.
  12. Doloff JC#, Ma M, Sadraei A, Tam HH, Farah S, Hollister-Lock J, Vegas AJ, Veiseh O, Quiroz VM, Rakoski A, Aresta-DaSilva S, Bader AR, Griffin M, Weir GC, Brehm MA, Shultz LD, Langer R, Greiner DL#, Anderson DG#. Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response. Science Advances. 2023 Jun 16;9(24). doi: 10.1126/sciadv.ade9488.
  13. Neshat SY, Chan CHR, Harris J, Zmily OM, Est-Witte S, Karlsson J, Shannon SR, Jain M, Doloff JC, Green JJ, Tzeng SY. Polymeric nanoparticle gel for intracellular mRNA delivery and immunological reprogramming of tumors. Biomaterials. 2023 Sep;300. doi: 10.1016/j.biomaterials.2023.122185.
  14. Neshat SY, Bauer SJ, Rhodes KR, Quiroz VM, Wong VW, Lowmaster SM, Tzeng SY, Green JJ#, Doloff JC#. Improvement of Islet Engrafts via Treg Induction Using Immunomodulating Polymeric Tolerogenic Microparticles. ACS Biomater Sci Eng. 2023 Jun 12;9(6):3522-3534. doi: 10.1021/acsbiomaterials.3c00329.
  15. Herrera-Mora G, Solis-Chaves P, Hernandez-Aviles G, Graham EM, Clausen-Oreamuno C, Castro-Cespedes JA, Haupt J, Jamiel M, Veiseh O, Sforza M, Hancock J, Kinney B, De Mezerville R, Langer R#, Doloff JC#, Chacon-Quiros M#. Ultrasonographic Identification of Shell Surface Types in Commercially Available Silicone Gel-Filled Breast Implants. Plast Reconstr Surg. 2023 May 24. doi: 10.1097/PRS.0000000000010758.
  16. Wilson DR, Tzeng SY, Rui Y, Neshat SY, Conge MJ, Luly KM, Wang E, Firestone JL, McAuliffe J, Maruggi G, Jalah R, Johnson R, Doloff JC, Green JJ. Biodegradable Polyester Nanoparticle Vaccines Deliver Self-Amplifying mRNA in Mice at Low Doses. Advanced Therapeutics. 2023 Feb 16. doi: 10.1002/adtp.202200219.
  17. Holzer P, Chang EJ, Rogers K, Tarlton J, Lu D, Gillespie N, Adkins J, Metea M, LaRochelle A, Wicks J, Onel B, Gullans S, Doloff JC, Scobie L, Cetrulo CL Jr, Monroy R. Large-gap peripheral nerve repair using xenogeneic transplants in rhesus macaques. Xenotransplantation. 2023 Mar;30(2). doi: 10.1111/xen.12792.
  18. Abramson HG, Curry EJ, Mess G, Thombre R, Kempski-Leadingham KM, Mistry S, Somanathan S, Roy L, Abu-Bonsrah N, Coles G, Doloff JC, Brem H, Theodore N, Huang J, Manbachi A. Automatic detection of foreign body objects in neurosurgery using a deep learning approach on intraoperative ultrasound images: From animal models to first in-human testing. Front Surg. 2022 Nov 30;9. doi: 10.3389/fsurg.2022.1040066.
  19. Weber-Levine C, Hersh AM, Jiang K, Routkevitch D, Tsehay Y, Perdomo-Pantoja A, Judy BF, Kerensky M, Liu A, Adams M, Izzi J, Doloff JC, Manbachi A, Theodore N. Porcine Model of Spinal Cord Injury: A Systematic Review. Neurotrauma Rep. 2022 Sep 1;3(1):352-368. doi: 10.1089/neur.2022.0038.
  20. Bauer SJ and Doloff JC. Less Fibrosis around silicone implants. Nature BiomedEng. 2021 Dec;(20):1407-1408. doi: 10.1038/s41551-021-00830-w.
  21. Lai V, Neshat SY, Rakoski A, Pitingolo J, Sabedra J, Li S, Shodhan A, and Doloff JC. Crystallization of the Multi-Receptor Tyrosine Kinase Inhibitor Sorafenib for Controlled Long-Term Drug Delivery Following a Single Injection. CMBE (Young Innovators). 2021 Oct 18;14(5):471-486. doi: 10.1007/s12195-021-00708-6.
  22. Lai V, Neshat SY, Rakoski A, Pitingolo J, and Doloff JC. Drug delivery strategies in maximizing anti-angiogenesis and anti-tumor immunity. Adv Drug DelivRev. 2021 Dec;(179):113920. doi: 10.1016/j.addr.2021.113920.
  23. Neshat SY, Quiroz VM, Wang Y, Tamayo S, Doloff JC. Liver Disease: Induction, Progression, Immunological Mechanisms, and Therapeutic Interventions. Int J Mol Sci. 2021 Jun 24;22(13). doi: 10.3390/ijms22136777.
  24. Doloff JC*#, Veiseh O*#, de Mezerville R#, Sforza M, Perry TA, Haupt J, Jamiel M, Chambers C, Nash A, Aghlara-Fotovat S, Stelzel JL, Bauer SJ, Neshat SY, Hancock J, Romero NA, Hidalgo YE, Leiva IM, Munhoz AM, Bayat A, Kinney BM, Hodges HC, Miranda RN, Clemens MW, & Langer R#. The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans. Nature Biomed Eng. 2021 June 21; doc: 10.1038/s41551-021-00739-4.
  25. Stelzel J and Doloff JC. MAP-ing a way towards tissue repair. Nature Materials. 2021 Mar 26;(20):452–453. doi: 10.1038/s41563-021-00963-y.
  26. Mao L, Li L, Huang Y, Delcassian D, Chahal J, Han J, Shi Y, Sadtler K, Lin J, Doloff JC, Langer RS, and Anderson DG. Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation. Nature Biotechnology. 2019 Sep 30. doi: 10.1038/s41587-019-0247-3.
  27. Farah S*, Doloff JC*, Mueller P, Sadraei A, Han HJ, Olafson K, Tyas K, Tam HH, Hollister-Locke J, Kowalski PS, Griffin M, Meng A, McAvoy M, Graham AC, McGarrigle J, Greiner DL, Weir G, Oberholzer J, Langer R, and Anderson DG. Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations. Nature Materials. 2019 Aug;18(8):892-904. doi: 10.1038/s41563-019-0377-5.
  28. Spanoudaki V, Doloff JC, Huang W, Norcross SR, Farah S, Langer R, and Anderson DG. Simultaneous spatiotemporal tracking and oxygen sensing of transient implants in vivo using hot-spot MRI and machine learning. PNAS. 2019 Feb 26. doi: 10.1073/pnas.1815909116.
  29. Bochenek MA, Veiseh O, Vegas AJ, McGarrigle JJ, Qi M, Marchese E, Omami M, Doloff JC, Mendoza-Elias J, Nourmohammadzadeh M, Khan A, Yeh C, Isa D, Ghani S, Li J, Landry C, Bader AR, Olejnik K, Chen M, Hollister-Lock J, Wang Y, Greiner DL, Weir GC, Strand BL, Rokstad AM, Lacik I, Langer R, Anderson DG, and Oberholzer J. Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques. Nature Biomed Eng. 2018 Aug 13. doi: 10.1038/s41551-018-0275-1.
  30. Xie X*, Doloff JC*, Yesilyurt V*, Sadraei A*, McGarrigle J, Omami M, Veiseh O, Isa D, Ghani S, Joshi I, Li J, Wang W, Tam HH, Tao J, Chen H, Yang B, Oberholzer J, Langer RS, Anderson DG. Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer. Nature Biomed Eng. 2018 July 30. doi: 10.1038/s41551-018-0273-3.
  31. Khan OF, Kowalski P*, Doloff JC*, Tsosie JK, Bakthavatchalu V, Bodi CW, Haupt J, Jamiel M, Langer R, and Anderson DG. Endothelial siRNA delivery in nonhuman primates using ionizable low–molecular weight polymeric nanoparticles. Science Advances. 2018 Jun 27;4(6):eaar8409. doi: 10.1126/sciadv.aar8409.
  32. Doloff JC, Veiseh O, Vegas AJ, Tam HH, Farah S, Ma M, Li J, Bader A, Chiu A, Sadraei A, Aresta-Dasilva S, Griffin M, Jhunjhunwala S, Webber M, Siebert S, Tang K, Chen M, Langan E, Dholokia, Thakrar R, Qi M, Oberholzer J, Greiner DL, Langer R, and Anderson DG. Colony Stimulating Factor-1 Receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates. Nature Materials. 2017 Mar 20. doi: 10.1038/nmat4866.
  33. Vegas AJ, Veiseh O, Doloff JC, Ma M, Tam HH, Bratlie K, Li J, Bader A, Langan E, Olejnik K, Fenton P, Kang JW, Hollister-Locke J, Bochenek MA, Chiu A, Siebert S, Tang K, Jhunjhunwala S, Aresta-Dasilva S, Dholokia N, Thakrar R, Vietti T, Cohen J, Siniakowicz K, Qi M, Lyle S, Harlan DM, Greiner DL, Oberholzer J, Weir GC, Langer RS, and Anderson DG. Combinatorial development of hydrogels that mitigate the foreign body response in primates. Nature Biotechnology. 2016 Mar;34(3):345-52. doi:10.1038/nbt.3462.
  34. Vegas AJ, Veiseh O, Gurtler M, Millman J, Paglicua F, Bader A, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, Greiner DL, Weir GC, Melton DA, Langer R, and Anderson DG. Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice. Nature Medicine. 2016 Mar;22(3):306-11. doi:10.1038/nm.4030.
  35. Veiseh O*, Doloff JC*, Ma M*, Vegas AJ, Tam HH, Bader AR, Li J, Langan E, Wyckoff J, Loo WS, Jhunjhunwala S, Chiu A, Siebert S, Tang K, Hollister-Locke J, Aresta-Dasilva S, Bochenek M, Mendoza-Elisa J, Wang Y, Qi M, Lavin D, Chen M, Dholokia N, Thakrar R, Lacik I, Weir GC, Oberholzer J, Greiner DL, Langer R, and Anderson DG. Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates. Nature Materials. 2015 Jun; 14(6):643-51.
  36. Doloff JC*, Chen CS*, and Waxman DJ. Anti-tumor innate immunity activated by metronomic cyclophosphamide treatment of 9L brain tumor xenografts is preserved by anti-angiogenic drugs that spare VEGF receptor 2. Molecular Cancer. 2014 Jun 26; 13(1): 158.
  37. Chen CS*, Doloff JC*, and Waxman DJ. Intermittent metronomic drug schedule is essential for activating anti-tumor innate immunity and tumor xenograft regression. Neoplasia. 2014 Jan; 16(1): 84-96.
  38. Doloff JC and Waxman DJ. VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression. Cancer Research, 2012 Mar 1; 72(5): 1103-15.