Systems Biology connects the information in our genome and epigenome and the function of biological systems, from cells to tissues and organs. Johns Hopkins researchers are developing new computational and experimental methods for systematic analysis of biological systems, building models that span scales of length and time, and using synthetic biology for de novo design of new biomedical systems. Among applications are cancer, cardiovascular, neurological, and infectious diseases.
Developing new technologies to determine the sequence and epigenetic modifications of individual DNA molecules for personalized medicine.
Reprogramming cellular behavior and engineering cell fate
Learning how information in DNA provides spatiotemporal control of gene expression and directing cell fate transitions.
Developing personalized computational models
Predicting how personal genetic, epigenetic, and genomic variation affect disease risk and therapeutic response.
De novo design of genes, pathways, chromosomes, and genomes
Designing, fabricating, and integrating new biological components from individual genes to entire chromosomes and genomes.
Harnessing next-generation biological and engineering approaches to fathom the full complexity of the networks of molecules and cells that control the processes of life and lie at the heart of human health.