Research

Genomics & Systems Biology

Genomics & Systems Biology connects the information in our genome and epigenome to the function of biological systems, from cells to tissues and organs. We are developing new computational and experimental methods for the systematic analysis of genomes, building models that span length and time scales, and using synthetic biology to design new biomedical systems for human health applications.

Research in Genomics & Systems Biology

Our students and faculty are pioneering new technologies to understand how the interactions between molecules, cells, tissues, and organs maintain health and contribute to disease. Key research areas include:

Genome Assembly

We are developing novel genome assembly methods that can reconstruct genomes of all sizes from the latest sequencing technologies.

Transcriptomics and RNA Sequencing

We are building computational methods to transform data into accurate readouts of gene activity and compare gene expression across conditions.

Personal Genomics and Data Modeling

We are developing new methods for large-scale integrated analysis of genomic, epigenomic, and transcriptomic data to better predict the impact of genetic variants on human health.

Genomic and Epigenomic Engineering

We are using new tools to edit the genome and epigenome, and identifying links between the environment and genetics to prevent and treat disease.

Nanopore Sequencing

We are developing new technologies to determine the sequence and epigenetic modifications of individual DNA molecules for personalized medicine.

Engineering Cell Fate

We are directing cell fate transitions by learning how genomes provide spatiotemporal control of gene expression.

Synthetic Biology

We are designing, fabricating, and integrating new biological components, ranging from individual genes to entire chromosomes and genomes.

Core Faculty