News & Events

Research highlights

March 1, 2012

Levchenko group nabs Science Signalling cover

A paper by Andre Levchenko, Professor of Biomedical Engineering, and collaborators was featured on the cover of the Feb 28 issue of Science Signalling. The paper, titled “Diverse Sensitivity Thresholds in Dynamic Signaling Responses by Social Amoebae,” was featured in a Focus Issue on cell migration and chemotaxis. The image shows Dictyostelium cells streaming toward […]

Read on.

October 27, 2011

Information theory helps predict biological signaling

Andre Levchenko, associate professor of BME, and his lab have described techniques that enable use of information theory in analysis of biological decision making, particularly in networks of signaling pathways. The first-of-its-kind study, published on September 15 in Science combines live-cell experiments and math to convert the inner workings of the cell decision-making process into […]

Read on.

September 30, 2011

BME researchers develop novel approach to defibrillation

Three research labs at Hopkins—the Tung and Trayanova labs in Biomedical Engineering and the Berger lab in Cardiology—have combined forces to investigate the efficacy of high frequency alternating current as an alternative to conventional waveforms used to defibrillate the heart. This research could lead to defibrillator devices that apply a more gentle, less painful current […]

Read on.

September 8, 2011

Research from Trayanova lab published in Science Translational Medicine

Trayanova Lab has been collaborating with the laboratory of Dr. Colleen Clancy at UC Davis, Department of Pharmacology, as well as researchers from Columbia and Cornell University to develop a computer model of a human heart that can help forecast some of the side effects of drugs used to treat cardiac tachyarrhythmias. A research article […]

Read on.

December 10, 2010

Collaborators in BME and Medicine shed light on insulin production

Andre Levchenko, Associate Professor in BME and Jin Zhang, Dept. of Pharmacology have published a paper in Nature Chemical Biology revealing their discovery of a tunable circuit in pancreatic cells that integrates and interprets incoming hormonal, metabolic and electrical signals to determine how to generate the cell’s output of insulin. Levchenko’s team’s contribution was to […]

Read on.

October 1, 2010

Karchin paper highlighted in editorial

Rachel Karchin, assistant professor of the Department of Biomedical Engineering and the Institute for Computational Medicine, and colleagues have created a computer program to help predict which changes in the DNA code may cause pancreatic cells to become cancerous. Cells in the body accumulate DNA changes over time as a result of the normal aging […]

Read on.

August 5, 2010

Trayanova paper featured on cover of Biophysical Journal

“Distribution of Electromechanical Delay in the Heart: Insights from a Three-Dimensional Electromechanical Model” by V. Gurev, J. Constantino, J. J. Rice, and N. A. Trayanova was published in and featured on the cover of Biophysical Journal. The picture on the laptop screen shows the heterogeneous spatial distribution of the electromechanical delay during sinus rhythm (left) […]

Read on.

August 3, 2010

Levchenko paper highlighted in Nature Nanotechnology

Nature Nanotechnology not only published Andre Levchenko’s paper, “Subcellular-resolution delivery of a cytokine through precisely manipulated nanowires,” but also gave it a shout-out in the “News and Views” column titled “Nanobiotechnology: Nanowires have cells in their sights” as an example of nanotechnology that is allowing biological processes to be studied in greater detail. The work […]

Read on.

February 19, 2010

Yue lab calcium signaling study published in Nature

BME faculty member David Yue and colleagues Xiaodong Liu, Phil Yang, and Wanjun Yang, all of the Calcium Signals Laboratory, have published a study in the international journal Nature (Advanced Online Publication 2/7/2010, http://www.nature.com/nature/journal/v463/n7283/abs/nature08766.html). The authors simultaneously combined patch-clamp electrophysiology to characterize calcium ion channel function with genetically-encoded optical sensors to measure cell signaling factors, […]

Read on.

BME's Leslie Tung, left, and Andre Levchenko, right, with Deok-Ho Kim, a doctoral student in Levchenko's lab.

February 1, 2010

Heart cells display ‘nano sense’ on new lab chip

Johns Hopkins Department of Biomedical Engineering faculty Andre Levchenko and Les Tung along with colleagues in Korea have found that heart cell and tissue properties can be controlled by varying the nano-scale topography of the scaffolds supporting the cells, a surprising indication that heart cells possess a ‘nano-sense’ capable of responding to minute differences in […]

Read on.