News & Events

Research highlights

December 10, 2010

Collaborators in BME and Medicine shed light on insulin production

Andre Levchenko, Associate Professor in BME and Jin Zhang, Dept. of Pharmacology have published a paper in Nature Chemical Biology revealing their discovery of a tunable circuit in pancreatic cells that integrates and interprets incoming hormonal, metabolic and electrical signals to determine how to generate the cell’s output of insulin. Levchenko’s team’s contribution was to […]

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October 1, 2010

Karchin paper highlighted in editorial

Rachel Karchin, assistant professor of the Department of Biomedical Engineering and the Institute for Computational Medicine, and colleagues have created a computer program to help predict which changes in the DNA code may cause pancreatic cells to become cancerous. Cells in the body accumulate DNA changes over time as a result of the normal aging […]

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August 5, 2010

Trayanova paper featured on cover of Biophysical Journal

“Distribution of Electromechanical Delay in the Heart: Insights from a Three-Dimensional Electromechanical Model” by V. Gurev, J. Constantino, J. J. Rice, and N. A. Trayanova was published in and featured on the cover of Biophysical Journal. The picture on the laptop screen shows the heterogeneous spatial distribution of the electromechanical delay during sinus rhythm (left) […]

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August 3, 2010

Levchenko paper highlighted in Nature Nanotechnology

Nature Nanotechnology not only published Andre Levchenko’s paper, “Subcellular-resolution delivery of a cytokine through precisely manipulated nanowires,” but also gave it a shout-out in the “News and Views” column titled “Nanobiotechnology: Nanowires have cells in their sights” as an example of nanotechnology that is allowing biological processes to be studied in greater detail. The work […]

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February 19, 2010

Yue lab calcium signaling study published in Nature

BME faculty member David Yue and colleagues Xiaodong Liu, Phil Yang, and Wanjun Yang, all of the Calcium Signals Laboratory, have published a study in the international journal Nature (Advanced Online Publication 2/7/2010, http://www.nature.com/nature/journal/v463/n7283/abs/nature08766.html). The authors simultaneously combined patch-clamp electrophysiology to characterize calcium ion channel function with genetically-encoded optical sensors to measure cell signaling factors, […]

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BME's Leslie Tung, left, and Andre Levchenko, right, with Deok-Ho Kim, a doctoral student in Levchenko's lab.

February 1, 2010

Heart cells display ‘nano sense’ on new lab chip

Johns Hopkins Department of Biomedical Engineering faculty Andre Levchenko and Les Tung along with colleagues in Korea have found that heart cell and tissue properties can be controlled by varying the nano-scale topography of the scaffolds supporting the cells, a surprising indication that heart cells possess a ‘nano-sense’ capable of responding to minute differences in […]

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December 14, 2009

Levchenko co-author of PNAS study

BME faculty member Andre Levchenko is a co-author on a recently published PNAS study (Dec. 1, 2009) suggesting that a combination of gene and stem cell therapies can save limbs that might otherwise be in danger of amputation. The work was performed in collaboration with Gregg Semenza’s laboratory at Hopkins’ Institute for Cell Engineering. Blood […]

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October 20, 2009

Growing bone in exact shapes

Picture series showing the bone matrix as it develops. BME faculty member Warren Grayson, along with colleagues Gordana Vunjak-Novakovic and others, have grown bone grafts in the exact shape of a desired bone, an advance that could help provide doctors with just what they need for face, skull and other skeletal reconstructions. Using real bone […]

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Rachel Karchin, right, an assistant professor of biomedical engineering, and doctoral student Hannah Carter led a Johns Hopkins team that developed software to narrow the search for mutations linked to cancer. Photo by Will Kirk.

September 14, 2009

Karchin computer program IDs likely cancer mutations

Johns Hopkins assistant professor of biomedical engineering Rachel Karchin and doctoral student Hannah Carter led a Johns Hopkins team that developed innovative computer software that can sift through hundreds of genetic mutations and highlight the DNA changes that are most likely to promote cancer. The goal is to provide critical help to researchers who are […]

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July 28, 2009

Shadmehr autism work featured in Nature Neuroscience

An article, “Representation of internal models of action in the autistic brain,” summarizing work by Reza Shadmehr, members of his lab and colleagues, was published in the August 2009 issue of Nature Neuroscience. The abstract states: “Children with autism spectrum disorder (ASD) have deficits in motor control, imitation and social function. Does a dysfunction in […]

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