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Research highlights

Brain Changes Linked With Alzheimer’s Years Before Symptoms Appear

May 20, 2019

Brain changes linked with Alzheimer’s years before symptoms appear

In a records review of 290 people at risk for Alzheimer’s disease, scientists at Johns Hopkins say they have identified an average level of biological and anatomical brain changes linked to Alzheimer’s disease that occur three to 10 years — some even more than 30 years — before the disease’s first recognizable symptoms appear.

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Maps of tumors grown in mice.

May 6, 2019

‘Google Maps’ for cancer: Image-based computer model reveals finer details of tumor blood flow behavior

Johns Hopkins Medicine researchers develop an image-based computer model of tumor behavior that captures more of the complexity of cancer growth.

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Sequenced genome sizes

April 25, 2019

Johns Hopkins teams up with U.C. Davis and Save the Redwoods League to sequence the first coast redwood genome

Steven Salzberg, Bloomberg Distinguished Professor of biomedical engineering at Johns Hopkins University, collaborated with researchers from the University of California, Davis and Save the Redwoods League to successfully sequence the coast redwood and giant sequoia genomes.

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T-cells interacting with the transparent gel.

April 18, 2019

Scientists advance creation of ‘artificial lymph node’ to fight cancer, other diseases

In a proof-of-principle study in mice, PhD candidate John Hickey and scientists at Johns Hopkins Medicine report the creation of a specialized gel that acts like a lymph node to successfully activate and multiply cancer-fighting immune system T-cells.

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Andrew Feinberg and Lindsay Rizzardi test procedures for storing blood samples on NASA’s microgravity plane.

April 11, 2019

After returning from space, astronaut has no lingering, major epigenetic differences from earthbound twin brother

In a landmark study, a group of U.S. scientists from Johns Hopkins, Stanford University and other institutions has found no long-lasting, major differences between the epigenomes of astronaut Scott Kelly, who spent a year in space aboard the International Space Station, and his twin brother, Mark, who remained on Earth.

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Experimental Drug Delivers One-Two Punch to Vision Loss

April 10, 2019

Experimental drug delivers one-two punch to vision loss

In studies with lab-grown human cells and in mice, Aleksander Popel and other Johns Hopkins Medicine researchers have found that an experimental drug may be twice as good at fighting vision loss as previously thought.

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Mini microscope

April 1, 2019

Mini microscope is the new GoPro for studies of brain disease in living mice

Working with mice, a team of Johns Hopkins Medicine researchers has developed a relatively inexpensive, portable mini microscope that could improve scientists’ ability to image the effects of cancer, stroke, Alzheimer’s disease and other conditions in the brains of living and active mice over time.

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New computer program reduces spine surgery errors linked to “wrong level” labeling

February 6, 2019

New computer program reduces spine surgery errors linked to “wrong level” labeling

Researchers at Johns Hopkins report that a computer program they designed may help surgeons identify and label spinal segments during real time operating room procedures and avoid the costly and potentially debilitating consequences of operating on the wrong segment.

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STUDY DEFINES DIFFERENCES AMONG BRAIN NEURONS THAT COINCIDE WITH PSYCHIATRIC CONDITIONS

January 16, 2019

Study defines differences among brain neurons that coincide with psychiatric conditions

In a new study focusing on four regions of normal human brain tissue, Johns Hopkins scientists have found about 13,000 regions of epigenetic differences between neurons in different brain regions that vary by at least 10 percent.

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Johns Hopkins study sheds light on brain basis of risk-taking behavior

January 7, 2019

How the brain decides whether to hold ’em or fold ’em

A team led by Sridevi Sarma, associate professor of biomedical engineering at Johns Hopkins, has found that the decision to “up the ante” even in the face of long odds is the result of an internal bias that adds up over time and involves a “push-pull” dynamic between the brain’s two hemispheres.

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