Xingde Li, PhD


Professor, Biomedical Engineering, SOM
Professor, Electrical and Computer Engineering, WSE
Professor, Oncology, SOM
Fellow of OSA, SPIE and AIMBE

Office: Traylor 710
Lab: Laboratory of Biophotonics Imaging Technologies (BIT)


BS, Physics, University of Science and Technology of China (USTC), 1990
PhD, Physics and Biomedical Optics, University of Pennsylvania (UPenn), 1998

Research Interests

My research interest centers on development of cutting-edge and translational biophotonics technologies that interface and bridge basic engineering research and medical diagnosis and intervention. The research and training involves vertical integration of multiple disciplines, including (but not limited to) optics, electrical engineering, micro-nano technology, biology and clinical medicine. The ultimate goal of our research is to transform our capability of disease detection at early, manageable stages, monitoring therapeutic effects and treatment outcomes, and guiding interventions. The technologies also offer new opportunities for basic research in exploring new frontiers of disease mechanisms, brain function, bio-marker discovery and integrated diagnosis and therapy. Some specific research interests include:

  • Optical Coherence Tomography (OCT)
  • Multiphoton Endomicroscopy
  • Label-free Mass-spectrometry Imaging (MSI)
  • NIR Fluorescence Imaging
  • Functional Nanocapsules and Nanoparticles for Molecular Imaging
  • Noninvasive Cancer Detection, Infection and Inflammation Detection, Preterm Birth Assessment, Wound Healing Imaging and Surgical Guidance
  • In vivo Cellular Metabolism Imaging, Brain Function Imaging

Selected Publications

From Pub Med   |   Google Scholar Profile

Publications Search

Cobb MJ, Hwang JH, Upton MP, Chen YC, Oelschlager BK, Wood DK, Kimmey MB, Li XD. “Imaging of subsquamous Barrett’s epithelium with ultrahigh-resolution optical coherence tomography: a histologic correlation study,” Gastrointestinal Endoscopy 71(2):223-230 (2010) (cover page).

Zhang YY, Akins ML, Murari K, Xi JF, Li MJ, Luby-Phelps K, Mahendroo M, Li XD. “A compact fiber-optic SHG scanning endomicroscope and its application to visualize cervical remodeling during pregnancy,” Proceedings of National Academy of Sciences-USA 109(32):12878-12883 (2012).

Toghi Eshghi S, Yang S, Wang XC, Shah P, Li XD, Zhang H. “Imaging of N-linked Glycans from Formalin-fixed Paraffin-embedded Tissue Sections Using MALDI Mass Spectrometry,” ACS Chemical Biology 9(9):2149-56 (2014).

Kut C, Chaichana KL, Xi JF, Raza SM, Ye X, McVeigh ER, Rodriguez FJ, Quiñones-Hinojosa A, Li XD. “Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography,” Science Translational Medicine 7(292):292ra100-292ra100 (2015).

Liang WX, Hall G, Messerschmidt B, Li MJ, and Li XD. “Nonlinear optical endomicroscopy for label-free functional histology in vivo,” Nature Light: Science and Applications 6:e17082 (2017).

Yuan W, Brown R, Mitzner W, Yarmus L, and Li XD. “Super-achromatic monolithic microprobe for ultrahigh-resolution endoscopic optical coherence tomography at 800 nm,” Nature Communications 8(1), 1531, (2017).

Juarez-Chambi R, Kut C, Rico-Jimenez J, Chaichana K, Xi JF, Campos-Delgado D, Rodriguez F, Quiñones-Hinojosa A, Li XD, and Jo J. “AI-Assisted In Situ Detection of Human Glioma Infiltration Using a Novel Computational Method for Optical Coherence Tomography,” Clinical Cancer Research 25(21), 6329-6338, (2019).

Yuan W, Chen DF, Sarabia-Estrada R, Guerrero-Cázares H, Li DW, Quiñones-Hinojosa A, and Li XD. “Theranostic OCT microneedle for fast ultrahigh-resolution deep-brain imaging and efficient laser ablation in vivo,” Science Advances 6(15), eaaz9664, (2020).

Guo PF, Li DW, and Li XD. “Deep OCT image compression with convolutional neural networks,” Biomedical Optics Express 11(7), 3543-3554, (2020).

Park HC, Guan H, Li A, Yue Y, Li MJ, Lu H, and Li XD. “High-Speed Fiber-optic Scanning Nonlinear Endomicroscopy for imaging Neuron Dynamics in vivo,” Optics Letters 45(13), 3605-3608, (2020).