Assistant Research Professor
Office: Smith 5039
Lab: Biomaterials and Drug Delivery Laboratory
Postdoctoral Associateship, Chemical Engineering, Massachusetts Institute of Technology, 2014-2017
PhD, Biomedical Engineering, Johns Hopkins University, 2014
BS, Biomedical Engineering, Yale University, 2009
Stephany Tzeng is a Research Associate in Biomedical Engineering and is part of the Translational Tissue Engineering Center (TTEC). She was awarded a Siebel Scholarship in 2014 while finishing her PhD work at Johns Hopkins on non-viral gene delivery nanoparticles for cancer therapy and regenerative medicine, advised by Jordan Green in the Biomaterials and Drug Delivery Lab. She completed a postdoctoral associateship at Massachusetts Institute of Technology on the use of synthetic biomaterials for vaccine delivery, including work published in PNAS in 2018 and in Science in 2017.
Her current work combines the non-viral gene delivery technology with recent advances in cancer immunotherapy, leveraging the synthetic nanoparticles as a safe and effective method of reprogramming the tumor microenvironment to activate the patient’s own immune system against cancer. She was also awarded a Young Investigator Grant from the American Autoimmune-Releated Diseases Association (AARDA) for her work on biodegradable cell mimics that can activate protective elements of the immune system in the case of autoimmune diseases.
Tzeng SY, McHuch KJ, Behrens AM, Rose S, Sugarman JL, Ferber S, Langer RS, Jaklenec A. 2018. Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response. Proc. Natl. Acad. Sci. U.S.A. 115(23):E5269-E5278
Kim J, Lima e Silva R, Shmueli RB, Mirando AC, Tzeng SY, Pandey NB, Ben-Akiva E, Popel AS, Campochiaro PA, Green JJ. 2019. Anisotropic poly(lactic-co-glycolic acid) microspheres enable sustained release of a peptide for long-term inhibition of ocular neovascularization. Acta Biomaterialia.
Vaughan HJ, Green JJ, Tzeng SY. 2019. Cancer-targeting nanoparticles for combinatorial nucleic acid delivery. Adv. Mater. https://doi.org/10.1002/adma.201901081
Kozielski KL, Ruiz-Valls A, Tzeng SY, Guerrero-Cazares H, Rui Y, Li Y, Vaughan HJ, Gionet-Gonzalez M, Vantucci C, Kim J, Schiapparelli P, Al-Kharboosh R, Quinones-Hinojosa A, Green JJ. 2019. Cancer-selective nanoparticles for combinatorial siRNA delivery to primary GBM in vitro and in vivo. Biomaterials 209:79-87.