Reza Kalhor, PhD
Office: Rangos 570
Lab: Kalhor Lab
Postdoctoral Fellowship, Harvard Medical School, 2012-2019
PhD, Molecular and Computational Biology, University of Southern California, 2012
BS, Biotechnology, University of Tehran, 2006
Dr. Kalhor’s research areas include synthetic biology, cell and genome engineering, and developmental biology. He specializes in using nucleic acids as a medium to record, transmit, process, and store biological and non-biological information. The Kalhor Lab is developing new DNA-based recording tools for high throughput, high resolution mapping of mammalian development, with a focus on brain development and developmental abnormalities. He is also studying novel ways of directly recording digital and analogue information into DNA. Kalhor’s work draws on molecular engineering, CRISPR-based manipulation, and computational approaches.
Dr. Kalhor received his PhD in Molecular and Computational Biology from USC, where he studied the relationship between genome function and its 3D structure. His postdoctoral training at the Harvard Medical School Department of Genetics and Wyss Institute focused on storage of digital and biological information in DNA. He joined the BME faculty in 2019.
Lee HH*, Kalhor R*, Goela N*, Bolot J, Church GM. Terminator-free template-independent enzymatic DNA synthesis for digital information storage. Nat Commun. 2019 Jun 3;10(1):2383. PMID: 31160595.
Kalhor R†, Kalhor K, Mejia L, Leeper K, Graveline A, Mali P, Church GM†. Developmental barcoding of whole mouse via homing CRISPR. Science. 2018 Aug 31;361(6405). pii: eaat9804. PMID: 30093604.
Kalhor R, Mali P, Church GM. Rapidly evolving homing CRISPR barcodes. Nat Methods. 2017 Feb;14(2):195-200. PMID: 27918539.
Lee JH, Daugharthy ER, Scheiman J, Kalhor R, Yang JL, Ferrante TC, Terry R, Jeanty SS, Li C, Amamoto R, Peters DT, Turczyk BM, Marblestone AH, Inverso SA, Bernard A, Mali P, Rios X, Aach J, Church GM. Highly multiplexed subcellular RNA sequencing in situ. Science. 2014 Mar 21;343(6177):1360-3. PMID: 24578530.
Kalhor R, Tjong H, Jayathilaka N, Alber F, Chen L. Genome architectures revealed by tethered chromosome conformation capture and population-based modeling. Nat Biotechnol. 2012 Jan;30(1):90-8. PMID: 22198700.