People

Rachel Karchin, PhD

Professor


The William R. Brody Faculty Scholar
Institute for Computational Medicine

Office: Hackerman 217A
Lab: Karchin Lab
410-516-5578
karchin@jhu.edu


Education

Ph.D., Computer Science, University of California, Santa Cruz, 2003
M.S., Computer Science, University of California, Santa Cruz, 2000
B.S., Computer Engineering, University of California, Santa Cruz, 1998

Research Interests

Genetic variation is critical to our susceptibility to diseases and response to medications. Yet the functional consequences of most genetic variants are unknown. We are working to predict these consequences using computation, by integrating information from molecular modeling and sequence analysis with clinical patient data and in vitro functional studies, through collaborations with physicians, genetic counselors, and experimental biologists. We are particularly interested in inherited cancer susceptibilities and gain of function mutations in tumor genomes.

Rachel is also the Diversity Champion representing BME.

Selected Publications

From Pub Med   |   Google Scholar Profile

Publications Search

Kuboki Y, Fischer CG, Beleva Guthrie V, Huang W, Yu J, Chianchiano P, Hosoda W, Zhang H, Zheng L, Shao X, Thompson ED, Waters K, Poling J, He J, Weiss MJ, Wolfgang CL, Goggins MG, Hruban RH, Roberts NJ, Karchin R, Wood LD. Single-cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesionsJ Pathol. 2018 Nov 14.