Patrick M. Boyle, PhD, PEng, FHRS
Assistant Research ProfessorInstitute for Computational Medicine
Office: Hackerman 217C
Lab: Computational Cardiology Laboratory
PhD, Biomedical Engineering, University of Calgary, 2011;
BSc, Computer Engineering, University of Calgary, 2005
The focus of my work is the development and application of sophisticated computer models of the human heart. Simulations executed using such models can be used to cultivate new knowledge about the underlying mechanisms of lethal cardiac arrhythmias and to develop novel strategies to treat these complex conditions. Patient-specific modeling of the human heart is now poised to address long-standing challenges in the field of cardiac electrophysiology, which is a truly thrilling prospect.
I am currently working on the development of simulation-based, custom-tailored atrial fibrillation ablation treatment plans based on each patient’s unique pattern of structural remodeling, as revealed by medical imaging.
I am also interested in using modeling to assess the feasibility of novel anti-arrhythmic devices based on emerging technologies, such as optogenetics. Simulations in this area can currently go far beyond what is possible in experimental and clinical research, meaning that insights from models will help guide and accelerate the engineering design process for the next generation of anti-arrhythmic devices.
Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations. Bruegman T*, Boyle PM*, […], Trayanova NA, Sasse P. J Clin Invest. 2016;126(10):3894-3904.
Patient-derived models link re-entrant driver localization in atrial fibrillation to fibrosis spatial pattern. Zahid S*, Cochet H*, Boyle PM*, […], Trayanova NA. Cardiovasc Res. 2016;110(3):443-454.
Opsin spectral sensitivity determines the effectiveness of optogenetic termination of ventricular fibrillation in the human heart: A simulation study. Karathanos TV, Bayer JD, Wang D, Boyle PM*, Trayanova NA*. J Physiol. 2016;594:6879–6891.
A comprehensive multiscale framework for simulating optogenetics in the heart. Boyle PM, Williams JC, Ambrosi CM, Entcheva E, Trayanova NA. Nat Commun. 2013;4:2370.
Purkinje-mediated effects in the response of quiescent ventricles to defibrillation shocks. Boyle PM, Deo M, Plank G, Vigmond EJ. 2010;38(2):456-468.
In the News
“Super new defibrillator ameliorates prognosis”
Babbage Podcast (The Economist)
“Future heart defibrillators could save lives with light pulses”
“Light could replace shock to regulate hearts”
The Baltimore Sun
“The Pacemakers of the Future Will Keep Your Heart Beating With Light”