Patrick Kanold, PhD
Office: Miller Research Building 379
Lab: The Kanold Lab
Post-Doctoral, Neurobiology, Harvard Medical School, 2000-2005
PhD, Biomedical Engineering, Johns Hopkins University, 2000
Dipl.Ing. (MSE), Electrical Engineering, Technische Universität Berlin, Germany, 1994
Animal and human communication uniquely depend on experience to learn which sound features are behaviorally relevant and which ones can be ignored. Our brains are uniquely adapted to solve quintessential survival problems that face an individual in its daily life. Thus, our brains must both accurately represent (encode) stimuli in the outside world and use that representation to generate appropriate behavioral actions. The sensory representation of the environment is established during early development and is further shaped by early life experience. Thus, to understand brain function we must understand how the brain circuitry adapts to its environment.
We apply engineering and systems neuroscience approaches to these crucial questions. We investigate the circuits present in the developing and adult brain, their function, and their influence of brain development and plasticity. One focus is on probing the response of the brain to sensory stimuli and the other is to analyze the function of small sub-circuits in detail. We are particularly interested in circuits that underlie the formation of the functional architecture of the auditory cortex and circuits underlying plasticity in both the very young (fetal and neonatal) and adult brain.
We use many different in vivo and in vitro approaches such as in vivo 2-photon Ca imaging, holographic optogenetic stimulation, patch clamp recordings, multi-electrode recordings, laser-scanning photostimulation, automated behavioral assays, etc.