Natalia Trayanova, PhD

Murray B. Sachs Professor

Department of Biomedical Engineeringand Institute for Computational Medicine

Office: Hackerman 216
Lab: Computational Cardiology Laboratory


PhD, Bulgarian Academy of Sciences (Sofia, Bulgaria), 1986
Post Doctoral Training, Biomedical Engineering, Duke University

Research Interests

Dr. Natalia Trayanova is the Murray B. Sachs Professor in the Department of Biomedical Engineering and the Institute for Computational Medicine, and directs the Computational Cardiology Laboratory at Johns Hopkins University. She is also a Professor in the Department of Medicine. In 2013, she received the NIH Director’s Pioneer Award for her project “Virtual Electrophysiology Laboratory”. She is a Fellow of the Heart Rhythm Society, American Heart Association, Biomedical Engineering Society, and the American Institute for Medical and Biological Engineering.

The translational research in Dr. Trayanova’s Computational Cardiology Laboratory centers around improvement of the clinical therapies of defibrillation and atrial and ventricular ablation, and the risk stratification for arrhythmias using a personalized MRI-based simulation approach. The basic science research in Dr. Trayanova lab focuses on understanding the pathological electrophysiological and electromechanical behavior of the heart, with emphasis on the mechanisms for cardiac arrhythmogenesis and pump dysfunction. Research in Dr. Trayanova’s laboratory is supported by grants from NIH, NSF, and the American Heart Association.

Dr. Trayanova has published extensively: as of September 2016 she is the author of over 230 peer-reviewed journal publications in prestigious journals (Science Translational Medicine, PNAS, Journal of Clinical Investigations, Nature Communications, Journal of American College of Cardiology, Circulation, Circulation Research, and others). Dr. Trayanova has presented at a large number of international meetings and has given numerous keynote and plenary lectures.

She and the members of her laboratory are the recipients of a large number of research awards. She has also received awards for excellence in teaching. Amongst her other professional activities, Dr. Trayanova serves currently as Associate Editor of the journals Heart Rhythm and Frontiers in Computational Physiology and Medicine; and is on the Editorial Board of a number of journals. Dr. Trayanova has served as a member of the NIH ESTA and MABS study sections as well as other study sections. Dr. Trayanova was the Vice-Chair in 2007 and the Chair in 2009 of the Gordon Research Conference on Cardiac Arrhythmia Mechanisms, and has served as a member of the program committee of a large number of international meetings. She currently serves on the FDA CIPA Steering Committee and the American Heart Association Research Funding Committee.

Selected Publications

From Pub Med   |   Google Scholar Profile

Publications Search

Y. Hu, V. Gurev, J. Constantino, J.D. Bayer, N.Trayanova. Effects of Mechano-Electric Feed- back on Scroll Wave Stability in Human Ventricular Fibrillation. PLoS ONE, 8(4): e60287. doi:10.1371/journal.pone.0060287, 2013.

N.Trayanova, Computational Cardiology: The Heart of the Matter, ISRN Cardiology (Spotlight Article), vol. 2012, Article ID 269680, 15 pages, 2012. doi:10.5402/2012/269680, 2012.

R Winslow, N Trayanova, D Geman, M Miller, The Emerging Discipline of Computational Medicine, Science Translational Medicine, 4, 158rv11, 2012.

Moreno J, Zhu I, Yang P-C, Bankston J, Jeng M-T,Kang C, Wang L, Bayer J, Christini D, Trayanova N, Ripplinger C, Kass R, Clancy C. A computational model to predict antiarrhythmic drug effects on cardiac rhythms. Science Translational Medicine, 3, 98ra83, 2011.

N Trayanova, Whole-heart modeling: Applications to cardiac electrophysiology and electrome- chanics, Circ Res, 108:113-128, 2011

Vadakkumpadan F, Arevalo H, Prassl A, Chen J, Kickinger F, Kohl P, Plank G, Trayanova N. Image-based models of cardiac structure in health and disease. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2:489-506, 2010.

Jie X, Gurev V, Trayanova N. Mechanisms of mechanically induced spontaneous arrhythmias in acute regional ischemia, Circ Res, 106:185-192, 2010.

S.M. Narayan, J. Bayer, G. Lalani, N. Trayanova. Alternans in phase II of human ventricular action potentials predicts long-term outcomes: A mechanism linking failing myocardium with arrhythmias, JACC, 52:1782-1792, 2008.

T. Ashihara, J. Constantino, N. Trayanova. Tunnel propagation of postshock activations as a hypothesis for fibrillation induction and isoelectric window, Circ Res 102:737-745, 2008.

B. Rodrguez, L. Li, J. Eason, I. Efimov, N. Trayanova. Differences between left and right ventricular chamber geometry affect cardiac vulnerability to electric shocks. Circ. Res. 97:168- 175, 2005