People
Leslie Tung Professor and Interim Director of Biomedical Engineering, Johns Hopkins University Faculty and students of the Johns Hopkins Department of Biomedical Enginerring have been breaking new ground in biomedical research for over 50 years and we strive to continue this history of innovation and discovery every day. More than 480 undergraduates and over 238 graduate students are enrolled in the Hopkins BME program, preparing themselves for careers in medicine, basic science, and industry. Each year a new class of 120 students from a stellar candidate pool, accept our offer of admission. The academic level of the program is extremely challenging — giving the best and brightest students an opportunity to obtain the most comprehensive training in

Leslie Tung, PhD

Professor

Professor of Biomedical Engineering

Office: Traylor 703
Lab: Cardiac Bioelectric Systems Laboratory
410-955-7453
ltung@jhu.edu


Education

B.S., M.S., Electrical Engineering, Massachusetts Institute of Technology, 1972
Ph.D., Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 1978

Research Interests

Engineering the Heart in a Dish

Our research involves the study of functional properties of engineered networks of living cardiac cells at varying structural levels that include single cells, cell strands, 2D sheets, and 3D tissue. We culture neonatal rat ventricular cells, human embyonic stem cell-derived cardiomyocytes and human induced pluripotent stem cell-derived cardiomyocytes as multicellular networks to investigate fundamental properties of action potential propagation and arrhythmias. The use of voltage-sensitive dyes and optical mapping allows us to follow the temporal and spatial patterns of electrical activity.

Our work is currently directed within the following areas:

  • Functional properties of cardiomyocytes derived from human pluripotent stem cells
  • Engineered cardiac tissues
  • High frequency alternating current for cardiac therapy
  • Myofibroblast-cardiomyocyte interactions More details are available on our lab website.

Selected Publications

From Pub Med
|   Google Scholar Profile

Publications Search

Blazeski, A., Zhu, R., Hunter, D. W., Weinberg, S. H., Zambidis, E. T., and Tung, L. Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility. Prog Biophys Mol Biol 110:166–177, 2012.

Weinberg, S. H., Chang, K. C., Zhu, R., Tandri, H., Berger, R. D., Trayanova, N. A., and Tung, L. Defibrillation success with high frequency electric fields is related to degree and location of conduction block. Heart Rhythm 10:740–748, 2013.

Joshi-Mukherjee, R., Dick, I. E., Liu, T., O’Rourke, B., Yue, D.T., and Tung, L. Structural and functional plasticity in long-term cultures of adult ventricular myocytes. J Mol Cell Cardiol 65:76–87, 2013.

Thompson, S. A., Blazeski, A., Copeland, C. R., Cohen, D. M., Chen, C. S., Reich, D. M., and Tung, L. Acute slowing of cardiac conduction in response to myofibroblast coupling to cardiomyocytes through N-cadherin. J Mol Cell Cardiol 68:29–37, 2014.