Lawrence P. Schramm, PhD
B.A., Engineering, Haverford College, 1961
Ph.D., Physiology, University of Rochester, 1970
For over thirty years, our laboratory has studied the derangements in blood pressure regulation after spinal cord injury. Many of these derangements are caused by failure of the spinal cord to process appropriately the inputs it receives from receptors from muscle, skin and internal organs. Recently, our laboratory focus has been on the spinal processing of this incoming activity using a variety of optogenetic methods in transgenic mice.
To fully engage in this research, I have closed my spinal cord injury laboratory, and I am working collaboratively with several laboratories in the Department of Neuroscience — combining our expertise in spinal cord anatomy and physiology, with their expertise in cellular and molecular biology.
This collaboration adds to the already numerous opportunities for Biomedical Engineering students to conduct highly quantitative, systems neuroengineering research in a rich neuroscience environment.
Zahner, M.R. and Schramm, L.P. Spinal regions involved in baroreflex control of renal sympathetic nerve activity in the rat. Am. J. Physiology., Regul. Integr. Comp. Physiol. R910–R916, 2011.
Zahner, M.R. Kulikowicz, E, Schramm, L.P. Recovery of baroreflex control of renal sympathetic nerve activity after spinal lesions in the rat. Am. J. Physiol., Regul Integr Comp Physiol. 301: R1584–1590, 2011.
Castillo DG, Zahner MR, Schramm LP. Identification of the spinal pathways involved in the recovery of baroreflex control after spinal lesions in the rat using pseudorabies virus. Am J Physiol Regul Integr Comp Physiol 303: R590–R598, 2012.
Mountney A, Zahner MR, Sturgill ER, Riley CJ, Aston JW, Oudega M, Schramm LP, Hurtado A, Schnaar RL. Sialidase, Chondroitinase ABC, and combination therapy after spinal cord contusion injury. J. Neurotrauma 30: 181–190, 2013.