Jude M. Phillip, PhD
Lab: Phillip tiME lab
Postdoctoral Associate, Melnick/Cerchietti labs, Weill Cornell Medicine, 2016-2020
PhD, Chemical and Biomolecular Engineering, Johns Hopkins University, 2015
B.Eng, Chemical Engineering, City College of New York, 2010
My research vision for the Phillip tiME lab, at the interface of engineering and medicine, focuses on applying fundamental engineering principles to answer key questions in aging and cancer biology. To this end, our long term goal is to develop and translate discoveries and technologies from the laboratory into the medical arena to improve human health and longevity. Our initial approach is built on two overarching concepts/needs, which are to develop robust cell-based biomarkers of aging in health and disease (with the ability to stratify vulnerable individuals), and to establish research pipelines that explain the mechanistic relationships among age-related dysfunctions, disease progression and treatment responses.
To address these anticipated challenges, my approach is to leverage emerging technologies in longitudinal cell-based profiling (including single cell biophysical properties and ‘omics’), combined with modern data science approaches and clinical measures to comprehensively assess health, identify deviations from healthy aging-trajectories and elucidate the scale-dependence of aging. We anticipate that these approaches will lead to effective strategies to reduce age-associated disease burdens, control healthcare costs by delaying onset and disease progression, and extend the amount of time spent free of diseases, dysfunctions and disabilities (due to improved risk prediction and early detection). Alongside these core questions, we are keen on identifying how gender, demographics, social determinants of health and health disparities contribute to the overall aging outlook of individuals, and the propensities for interventions and course correction.
Current projects include:
- Development and validation of cell-based biomarkers of aging in health and disease (frailty)
- Scale-dependence of aging—pathways for modifiable aging trajectories
- Understanding the role of age-induced stroma-immune crosstalk, and how it shapes lymphoma tumor immune-microenvironment (tiME)