Jordan J. Green, PhD
Director, Undergraduate ProgramProfessor of Biomedical Engineering, Ophthalmology, Oncology, Neurosurgery, Materials Science & Engineering, and Chemical & Biomolecular Engineering at the Johns Hopkins University School of Medicine
Office: Smith 5017
Lab: Biomaterials and Drug Delivery Laboratory
PhD, Biological Engineering, MIT, 2007
BS, Chemical Engineering, Biomedical Engineering, Carnegie Mellon University, 2003
Dr. Green’s Biomaterials and Drug Delivery Laboratory is interested in biomaterials, drug delivery, gene therapy, nanobiotechnology, and cell engineering. Research findings — and the technologies developed — are applied in the fields of ophthalmology, oncology, and regenerative medicine.
The lab works within the chemistry/biology/engineering interface to answer fundamental scientific questions, and to create innovative technologies and therapeutics that can directly benefit human health.
Current projects include:
- Development of safe and effective biodegradable nanoparticles for DNA and siRNA delivery to treat cancer
- Polymeric microparticle-based biological treatments for age-related macular degeneration
- Design of biomimetic artificial antigen presenting cells for immunoengineering
- Enabling technologies for tissue engineering and regenerative medicine
Randall A Meyer, Joel C Sunshine, Karlo Perica, Alyssa K Kosmides, Kent Aje, Jonathan P Schneck, Jordan J Green. Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Antigen Specific T-Cell Activation. Small 2015, 11 (13), 1519 –1525.
Antonella Mangraviti, Stephany Yi Tzeng, Kristen Lynn Kozielski, Yuan Wang, Yike Jin, David Gullotti, Mariangela Pedone, Nitsa Buaron, Ann Liu, David R Wilson, Sarah K Hansen, Fausto J Rodriguez, Guo-Dong Gao, Francesco DiMeco, Henry Brem, Alessandro Olivi, Betty Tyler, Jordan J Green. Polymeric Nanoparticles for Nonviral Gene Therapy Extend Brain Tumor Survival in Vivo. ACS nano 2015, 9 (2), 1236–1249.
CJ Bishop, B Abubaker-Sharif, T Guiriba, SY Tzeng, JJ Green. Gene delivery polymer structure-function relationships elucidated via principal component analysis. Chemical Communications 2015.
Hugo Guerrero-Cázares, Stephany Y Tzeng, Noah P Young, Ameer O Abutaleb, Alfredo Quiñones-Hinojosa, Jordan J Green. Biodegradable polymeric nanoparticles show high efficacy and specificity at DNA delivery to human glioblastoma in vitro and in vivo. ACS nano 2015 8 (5), 5141 –5153.
Green, J.J. 2011 Rita Schaffer Lecture: Nanoparticles for Intracellular Nucleic Acid Delivery. Annals of Biomedical Engineering 2012, 40(7):1408–18.
Bhise, N.S., Shmueli, R.B., Gonzalez, J., Green, J.J. A novel assay for quantifying the number of plasmids encapsulated by polymer nanoparticles. Small 2012, 8(3):367–73.
Sunshine, J.C., Sunshine, S., Bhutto, I., Handa, J., Green, J.J. Poly(ß-amino ester)-Nanoparticle Mediated Transfection Of Retinal Pigment Epithelial Cells in vitro and in vivo. PLoS ONE 2012, 7(5): e37543.
Tzeng, S.Y., Hung B.P., Grayson, W.L., and Green, J.J. Cystamine-terminated poly(beta-amino ester)s for siRNA delivery to human mesenchymal stem cells and enhancement of osteogenic differentiation. Biomaterials 2012, 33(32): 8142–51.
Sunshine, J.C., Peng, D.Y., Green, J.J. Uptake and transfection with polymeric nanoparticles are dependent on polymer end-group structure, but largely independent of nanoparticle physical and chemical properties. Molecular Pharmaceutics 2012, 9(11): 3375–83.
Tzeng, S.Y. and Green, J.J. Subtle changes to polymer structure and degradation mechanism enable highly effective nanoparticles for siRNA and DNA delivery to human brain cancer. Advanced Healthcare Materials 2013, 2(3):468–80.