Jeffrey H. Siewerdsen, PhD

John C. Malone Professor

Vice-Chair for Clinical and Industry Collaboration
Professor of Biomedical Engineering
Professor, Department Computer Science
Professor, Department of Neurosurgery
Professor, Russell H. Morgan Department of Radiology
Associate Faculty, Armstrong Institute for Patient Safety and Quality

Co-Director: Carnegie Center for Surgical Innovation

Principal Investigator: The I-STAR Lab

Office: Traylor 622
Lab: The I-STAR Lab

Research Interests

My goals are to bring breakthroughs in engineering, physics, and computer science to major challenges of human health, and to educate the next generation of leaders in biomedical imaging. My research involves the creation and clinical translation of new medical imaging technologies, techniques, and algorithms. Areas of major interest include:

  • Physics of image quality
  • Mathematical models of imaging performance
  • Design and optimization of new 3D imaging systems
  • Computed tomography (CT) and cone-beam CT (CBCT)
  • 3D image reconstruction
  • Image registration
  • Image analytics
  • Application to diagnostic and image-guided procedures.
Examples of my work are evident in systems that are now standard of care in image-guided radiation therapy (CBCT on linear accelerators), image-guided surgery (CBCT on mobile C-arms), and orthopaedics imaging (CBCT for weight-bearing extremities) as well as underlying algorithms for image reconstruction and registration. Intrinsic to such work is close clinical collaboration with radiologists, surgeons, and radiation oncologists to accelerate translation of concepts to first clinical application.
Such work also underlies my approach to educating the next generation of leaders in biomedical imaging not only in cutting-edge technologies and computational methods but also a deep appreciation of real clinical challenges and workflow.

Publications Search

From Pub Med   |   Google Scholar Profile

Selected Publications

Flat-panel cone-beam computed tomography for image-guided radiation therapy
DA Jaffray, JH Siewerdsen, JW Wong, AA Martinez
International journal of radiation oncology, biology, physics 53 (5), 1337-1349

Cone‐beam computed tomography with a flat‐panel imager: Magnitude and effects of x‐ray scatter
JH Siewerdsen, DA Jaffray
Medical physics 28 (2), 220-231

Volume CT with a flat‐panel detector on a mobile, isocentric C‐arm: Pre‐clinical investigation in guidance of minimally invasive surgery
JH Siewerdsen, DJ Moseley, S Burch, SK Bisland, A Bogaards, …
Medical physics 32 (1), 241-254 

Signal, noise power spectrum, and detective quantum efficiency of indirect‐detection flat‐panel imagers for diagnostic radiology
JH Siewerdsen, LE Antonuk, Y El‐Mohri, J Yorkston, W Huang, …
Medical physics 25 (5), 614-628 

Surgineering: curriculum concept for experiential learning in upper-level biomedical engineering
JH Siewerdsen, GL Adrales, WS Anderson, JP Carey, FX Creighton, …
International Journal of Computer Assisted Radiology and Surgery 15 (1), 1-14