Huang Guoliang

Guoliang Huang, PhD

Associate Professor, Tsinghua University

Office: Medical Sciences Building, Room B211


PhD, Optical Instrument, Tsinghua University (1995)
MS, Physics, Beijing Normal University (1991)
BS, Physics, Beijing Normal University (1988)

Research Interests

My research interests focus on the research and innovation of biomedical detection technology and instruments, including biochip detection, micro drop fiber-optic-sensing spectral analysis, microfluidic chip precision medicine molecular diagnosis, in situ measurement of living cells and assisted reproductive evaluation, small animal double mode coaxial and simultaneous in vivo molecular imaging, shadowless imaging of the white of human eye for the Chinese medicine eye-like health analysis, etc.

Major research achievements are as following:

  • Have finished more than 20 projects supported by the National Natural Science Foundation, 863 Chinese National Programs for High Technology Research and Development, 973 Key Project of the Chinese National Programs for Fundamental Research and Development, and the Foundations from the National Ministry of Science and Technology, or other provinces and municipalities. Twenty-two patents have also been authored, including seven international patents; the conversion rate of patent achievements is >70%.
  • More than 90 papers covering major achievements have been published in Lab on a Chip, Clinical Chemistry, Analytical Chemistry, Scientific Reports, Optics Letters, etc. The total SCI IF is >100; the highest single quote is >60; 9 articles are with SCI IF greater than 5; and 16 papers belong to top journals in the biochip field and authoritative journals in the biomedical engineering, optics and analysis fields. Three books were published, one of them is a national planning textbook; another won the Gold Award.
  • Actively promote “Production-Learning-Research-Medicine” collaborative innovation and industrialization of research results. Six scientific research achievements have been industrialized, and more than RMB 250 million Yuan and 6 million dollar direct economic benefits have been obtained. As well as two CFDA authorization of national innovating medical device product, one class-III and two class-II certificates of registration of medical device products, two CE certificates and two national standards were obtained.
  • Twenty National, Provincial and Ministerial and others awards have also been obtained, including Second prize for National Technology Invention from the People’s Republic of China Central People’s Government, Second prize for the Beijing Science and Technology Award from the Beijing Municipal People’s Government, First prize of the Science and Technology Award from the China Instrument and Control Society, etc.


Qi Li, Rongxin FuJunqi Zhang, Ruliang Wang, Jiancheng Ye, Ning Xue, Xue Lin, Ya Su, Wupeng Gan, Ying Lu, and Guoliang Huang*, A label-free method using weighted-phase algorithm to quantitate nanoscale interactions between molecules on DNA microarray, Analytical Chemistry, 2017, DOI:10.1021/acs. analchem.6b04596.

Junqi Zhang, Rongxin Fu, Liping Xie, Qi Li, Wenhan Zhou, Ruliang Wang, Jiancheng Ye, Dong Wang, Ning Xue, Xue Lin, Ying Lu and Guoliang Huang*A smart device for label-free and real-time detection of gene point mutations based on the high dark phase contrast of vapor condensationLab on a Chip, V15, p3891–3896, 2015.

Guoliang Huang*, Qin Huang, Li Ma, Xianbo Luo, Biao Pang, Zhixin Zhang, Ruliang Wang, Junqi Zhang, Qi Li, Rongxin Fu, and Jiancheng Ye, fM to aM nucleic acid amplification for molecular diagnostics in a non-stick-coated metal microfluidic bioreactor, Scientific Reports, V4(7344),p1-9, 2014.

Tongzhou Wang, Qiang Li, Xin Li, Songmin Zhao, Ying Lu and Guoliang Huang*, Use of hyperspectral imaging for label-free decoding and detection of biomarkers, Optics Letters,V38, p1524-26, 2013.

Xin Li, Zhuoqi Li, Wupeng Gan,Tongzhou Wang, Songmin Zhao,Ying Lu, Jing Cheng and Guoliang Huang*, Sensitive and High Resolution Subcutaneous Fluorescence in vivo Imaging Using Upconversion Nanoparticles and Microarray, Analyst, V138, p3711-3718, 2013.