Feilim Mac Gabhann, PhD
Associate Professor, Department of Biomedical Engineering and Institute for Computational Medicine
Office: Hackerman 316A
Lab: Microvascular Development and Remodeling Laboratory
Postdoctoral Fellow, Cardiovascular Research Center, University of Virginia
Ph.D., Biomedical Engineering, Johns Hopkins University
B.E., Chemical Engineering, University College Dublin
Inhibiting vascular endothelial growth factor signaling in cancer. Using druggable multiscale computational models of the transport and signaling of Vascular Endothelial Growth Factor (VEGF), we test therapies to block the signaling pathways that lead to vascularization of tumors and metastasis.
Promoting vascular endothelial growth factor signaling in ischemic disease. Using druggable multiscale computational models of the transport and signaling of Vascular Endothelial Growth Factor (VEGF), we test therapies to increase nonpathological pro-angiogenic signaling that lead to increased perfusion of muscle and other tissues vulnerable to ischemia.
Microvascular network organization. We study the variability in microvascular network structure in mice from different strains, both before and after intervention. Induced ischemic or other injury results in different remodeling responses that may hold the key to therapy development.
Impact of extracellular matrix on VEGF signaling. Using a combination of in vitro, in vivo and in silico approaches, we study the ability of extracellular matrix sequestration of VEGF to impact the extracellular VEGF signal as perceived by cell-surface receptors.
Molecular mechanisms of small-genome diseases: host-virus interactions of HIV. We have created molecular-level simulations of HIV, that complement existing models of viral development and cellular infection. By including the effects of the genes that HIV expresses, particularly those that have evolved to combat our host defenses, we can test new therapies that boost host antiviral responses.
Systems biology of vascular endothelial growth factors. Mac Gabhann F, Popel AS. Microcirculation. 2008 Nov;15(8):715–38. Review.
Skeletal muscle VEGF gradients in peripheral arterial disease: simulations of rest and exercise. Ji JW, Mac Gabhann F, Popel AS. Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3740-9.
Targeting neuropilin-1 to inhibit VEGF signaling in cancer: Comparison of therapeutic approaches. Mac Gabhann F, Popel AS. PLoS Comput Biol. 2006 Dec 29;2(12):e180.