Eun Hyun Ahn, PhD
Office: Ross 715B
Lab: Ahn Lab
Post-doctoral researcher, Pathology and Laboratory Medicine, University of Pennsylvania
Post-doctoral researcher, Human Nutrition, Columbia University
PhD, Biochemical Nutrition, Environmental Toxicology, Michigan State University
MS, Biochemical Nutrition, Michigan State University
BS, Chemistry, Home Economics Education, Chung-Ang University, Seoul, South Korea
In recent years, the Ahn lab has focused on the following areas: the detection of low-frequency mutations on a genome-wide level using a novel deep sequencing technology termed Duplex Sequencing (DS); and the regulation of cell function by microenvironments such as extracellular matrix (ECM)-biomimetic nanotopography. We have applied these cutting-edge experimental approaches to study genomic changes and migratory phenotypes of breast cancer and glioblastoma. The ultimate goals of the Ahn lab’s current and future research projects are to identify biomarkers for the early detection of therapy resistance and tumor recurrence using cutting-edge deep sequencing and ECM-biomimetics technologies, and to develop a novel strategy for preclinical screening of anti-migratory chemotherapeutic agents.
For more information on ongoing projects and recently completed projects, please visit the Ahn lab web page.
NanoMEA: a tool for high-throughput, electrophysiological phenotyping of patterned excitable cells. Nano Letters. 2020; 20(3):1561-1570 (Impact factor 12.3)
Extensive subclonal mutational diversity in human colorectal cancer and its significance. Proceedings of the National Academy of Sciences of the USA. 2019; 116(52):26863-26872 (Impact factor 9.8)
Immortalization of different breast epithelial cell types results in distinct mitochondrial mutagenesis. International Journal of Molecular Sciences 2019; 20(11):2813. doi:10.3390/ijms20112813 (Impact factor 4.2)
Decreased mitochondrial mutagenesis during transformation of breast stem cells to tumorigenic cells. Cancer Research 2016; 76(15):4569-4578 (Impact factor 9.3)
Detecting ultralow-frequency mutations by duplex sequencing. Nature Protocols 2014; 9:2586-2607 (Impact factor 11.3)
Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors. Science Signaling 2012; 5 (227): ra41 (Impact factor 6.5) Cover Article.[Highlighted in Science. The matter of the heart. Science 2012; 336:1483-1484. (Impact factor 41.1)]