Amir Manbachi, PhD
Assistant Research Professor
Associate Director of the BME Undergraduate Design ProgramAssociate Faculty, Armstrong Institute for Patient Safety and Quality
Office: Clark 208F
Postdoctoral Scholar, Brigham and Women’s Hospital, Harvard-MIT Division of Health Sciences and Technology, 2016
PhD, Biomedical Engineering, University of Toronto, Canada, 2015
MASc, Biomedical Engineering, University of Toronto, Canada, 2010
BASc, Engineering Science, University of Toronto, Canada, 2008
Dr. Manbachi’s research interests include engineering design, development and clinical validation of acoustic probes (ultrasound transducers) and minimally invasive medical devices for clinically inspired diagnoses and treatments.
With a research focus on acoustic probes and ultrasound transducers, the range of applications for these probes vary from imaging and image-guided interventions, to therapeutics (oncology ablations), Piezo-electric cutters, Thermometry, cell-localization and Neuromodulation.
Dr. Manbachi’s teaching activities include mentorship with BME Design Teams (teaching capstone design, innovation and entrepreneurship) as well as close collaboration with clinical experts in Surgery, Radiology and Human factor experts at Johns Hopkins.
His doctoral studies (conducted at the University of Toronto, under the supervision of Dr. Richard S.C. Cobbold) included design and development of ultrasound-guided spine surgery, which resulted in spinning off a startup. Subsequent to that, and prior to joining Johns Hopkins, he was a postdoctoral fellow at Harvard-MIT Division of Health Sciences and Technology (2015-16). He also has industry experience working at Stryker Navigation headquarters in Freiburg I’m Breisgau, Germany (2012).
Dr. Manbachi is an author on 25 peer-reviewed journal articles, 30+ conference proceedings, 10 invention disclosures / patent applications and a book entitled “Towards Ultrasound-guided Spinal Fusion Surgery.” His interdisciplinary research has been recognized by a number of awards, including University of Toronto’s 2015 Inventor of year award, and Ontario Brain Institute 2013 fellowship.
Dr. Manbachi has extensive teaching experience, particularly in the field of medical imaging and entrepreneurship both at Johns Hopkins and Toronto, for which he received the following two awards: University of Toronto’s Teaching Excellence award in 2014, as well as, Johns Hopkins University’s Whiting School of Engineering 2018 Robert B. Pond, Sr. Teaching Excellence Award.
Micah Belzberg, Francisco Chavez, Kah Timothy Xiong, Kyle Morrison, Nao Gamo, Stephen Restaino, Rajiv Iyer, Mari Groves, Nitish Thakor, Henry Brem, Alan Cohen, and Amir Manbachi “Minimally invasive intraventricular ultrasound: design and instrumentation towards a miniaturized ultrasound-guided focused ultrasound probe“, Proc. SPIE 10951, Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling, 109512Y (8 March 2019); doi: 10.1117/12.2513150
Belzberg M, Shalom NB, Yuhanna E, Manbachi A, Tekes A, Huang J, Brem H, Gordon CR. “Sonolucent Cranial Implants: Cadaveric Study and Clinical Findings Supporting Diagnostic and Therapeutic Transcranioplasty Ultrasound”. J Craniofac Surg. 2019 Mar . doi:10.1097/scs.0000000000005454. PMID: 30939550.
Manbachi A, De Silva T, Uneri A, Jacobson M, Goerres J, Ketcha M, Han R, Aygun N, Thompson D, Ye X, Vogt S, Kleinszig G, Molina C, Garzon-Muvdi T, Raber MR, Groves M, Wolinsky JP, Siewerdsen JH. “Clinical Translation of the LevelCheck Algorithm for Automatic Localization of Target Vertebrae in Spine Surgery”. Ann Biomed Eng (2018). https://doi.org/10.1007/s10439-018-2099-2
Brown AJV, Uneri A, De Silva TS, Manbachi A, Siewerdsen JH. “Design and validation of an open-source library of dynamic reference frames for research and education in optical tracking,” J. Med. Imag. 5(2) 021215 (9 February 2018)
Manbachi A, Kreamer-Tonin K, Walch P, Khoshakhlagh P, Zhang YS, Montague C, Acharya S, Logsdon EA, Allen RA, Durr NJ, Luciano MG, Theodore N, Brem H, Yazdi Y “Starting A Medical Technology Venture as an Young Academic Innovator or Student Entrepreneur” Ann Biomed Eng (2018) 46: 1.
Manbachi A, De Silva T, Uneri A, Jacobson M, Goerres J, Ketcha M, Han R, Aygun N, Thompson D, Ye X, Vogt S, Kleinszig G, Molina C, Garzon-Muvdi T, Raber MR, Groves M, Wolinsky JP, Siewerdsen JH. “Clinical Translation of the LevelCheck Algorithm for Automatic Localization of Target Vertebrae in Spine Surgery”. Presented at the “North American Spine Society” 2017 Annual Meeting, Orlando, Florida, USA.
Zhang X, Ellens NPK, Belzberg M, Miller P, Cohen AR, Brem H, Siewerdsen JH, Manbachi A. “Design of a Low-power, Minimally Invasive High Intensity Focused Ultrasound Device for Ablative Applications in Neuro-Oncology: A Simulation Study” Presented at the 59th AAPM (American Association of Physicists in Medicine) Annual Meeting & Exhibition (Denver, CO, 2017), abstract #37878.
Manbachi A. “Towards Ultrasound-guided Spinal Fusion Surgery” Springer Theses, Springer International Publishing (2016) ISBN 978-3-319-29832–0.
Manbachi A, Cobbold RSC, Ginsberg HJ, “Guided Pedicle Screw Insertion: Techniques and Training” Spine J. 2014; 14(1): 165–79.
Gdyczynski C, Manbachi A, Hashemi M, Lashkari B, Cobbold RSC, “On Estimating the directionality distribution in pedicle trabecular bone from micro-CT images” Physiol. Meas. 2014; 35(12): 2415–2428.
Manbachi A, Lee M, Foster FS, Ginsberg HJ, Cobbold RSC. “Design and fabrication of a low-frequency (1-3 MHz) ultrasound transducer for accurate placement of screw implants in the spine” Proc. SPIE 9040, Medical Imaging 2014: Ultrasonic Imaging and Tomography, 90400H (March 20, 2014); doi:10.1117/12.2042965.
Lashkari B, Manbachi A, Mandelis A, Cobbold RSC, “Slow and Fast Ultrasonic Wave separation improvement in human trabecular bones using Golay code modulation” JASA. 2012; 132(3), EL222–8.
Manbachi A, Cobbold RSC, “Development and Application of Piezoelectric Materials for Ultrasound Generation and Detection” Ultrasound 2011; 19(4): 187–196.
Manbachi A, Hoi Y, Wasserman BA, Lakatta EG, Steinman DA “On the Shape of the Common Carotid Artery, with Implications for Blood Velocity Profiles” Physiol Meas 2011; 32(12): 1885–97.
Manbachi A, Shrivastava S, Cioffi M, Chung BG, Moretti M, Demirci U, Yliperttula M, Khademhosseini A “Microcirculation within grooved substrates regulates cell positioning and cell docking inside microfluidic channels” Lab Chip. 2008; 8(5): 747–54.