![\"Complex](\"https:\/\/www.bme.jhu.edu\/dolofflab\/wp-content\/uploads\/2023\/12\/image-1024x1024.jpeg\")
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Lab Mission
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Welcome to the Doloff Lab for Immunoengineering and Regenerative Medicine. Our mission is to explore the intersection between therapeutics, whether biologic or synthetic in origin, and living systems to better understand what happens when deliverables are introduced into the body and how the host immune system behaves as well as perceives them.<\/p>\n\n\n\n
![\"Joshua](\"https:\/\/www.bme.jhu.edu\/dolofflab\/wp-content\/uploads\/2018\/12\/Joshua-C-Doloff-e1544457266539.png\")
Principal Investigator<\/h2>\n\n\n\n
Joshua C. Doloff<\/mark><\/a> is a newly appointed Associate Professor in Biomedical Engineering and Materials Science and Engineering at Johns Hopkins University\u2019s School of Medicine. He was previously a Juvenile Diabetes Research Foundation (JDRF) Senior Postdoctoral Fellow in the labs of Robert Langer and Daniel G. Anderson in Chemical Engineering and the David H. Koch Institute at MIT\/Children\u2019s Hospital Boston. Full Bio<\/mark><\/a><\/p>\n\n\n\n <\/p>\n\n\n\n Faculty Highlight: Meet Joshua Doloff, Assistant Professor of BME<\/em><\/strong><\/p>\n\n\n\n With an interest at the intersection of technology and biology, in this interview, Dr. Doloff describes his eagerness to build research collaborations and provide mentorship to students. He also discusses his \u201ceureka moments,\u201d the research he plans to conduct at Hopkins, and the future of engineering… continue reading<\/mark><\/a><\/p>\n\n\n\n Passion and mentoring are key to the success of the Doloff Lab<\/em><\/strong> (JHU News-Letter interview)<\/p>\n\n\n\n As a newly appointed Assistant Professor of Biomedical Engineering and Materials Science at the School of Medicine, Joshua Doloff is not only a research scientist advancing the fields of immunoengineering and regenerative medicine, but also a mentor to students… continue reading<\/mark><\/a><\/p>\n<\/div>\n<\/div>\n<\/div><\/div><\/div>\n\n\n\n ALL SELECTED PUBLICATIONS<\/mark><\/a><\/p>\n\n\n\n <\/p>\n<\/div><\/div>\n\n\n\n A team of researchers led by Joshua Doloff<\/mark><\/a>, an assistant professor of biomedical engineering, has discovered an advanced \u201chumanized\u201d mouse model to better predict how the human immune system will react to medical implants. Their results appear in Science Advances.<\/mark><\/a> …. FULL STORY HERE<\/mark><\/a><\/p>\n<\/div><\/div><\/div>\n\n\n\n Silicone breast implants with a smoother surface design have less risk of producing inflammation and other immune system reactions than those with more roughly textured coatings, according to new research by Joshua Doloff<\/mark><\/a>, assistant professor of biomedical engineering, who collaborated with researchers at Johns Hopkins Medicine, MIT, and Rice University on a series of experiments published last June in Nature Biomedical Engineering<\/mark><\/em><\/a>. …. FULL STORY HERE<\/mark><\/a><\/p>\n\n\n\n Implanted medical devices can save lives, but can also put patients at the risk of fibrosis, a condition in which the immune system attacks the device and produces scar tissue around it, interfering with the device\u2019s functionality. Working with researchers at Massachusetts Institute of Technology, Joshua Doloff, an assistant professor of biomedical engineering at Johns Hopkins University and former MIT postdoc, has devised a new way to prevent fibrosis: loading implantable devices with a crystallized immunosuppressant drug… FULL STORY HERE<\/mark><\/a><\/p>\n\n\n\n <\/p>\n<\/div><\/div>\n\n\n\n <\/p>\n","protected":false},"excerpt":{"rendered":" Lab Mission Welcome to the Doloff Lab for Immunoengineering and Regenerative Medicine. Our mission is to explore the intersection between therapeutics, whether biologic or synthetic in origin, and living systems to better understand what happens when deliverables are introduced into the body and how the host immune system behaves as well as perceives them. Select […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1671","page","type-page","status-publish","hentry"],"featured_image_src":null,"featured_image_src_square":null,"_links":{"self":[{"href":"https:\/\/www.bme.jhu.edu\/dolofflab\/wp-json\/wp\/v2\/pages\/1671","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bme.jhu.edu\/dolofflab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bme.jhu.edu\/dolofflab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bme.jhu.edu\/dolofflab\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bme.jhu.edu\/dolofflab\/wp-json\/wp\/v2\/comments?post=1671"}],"version-history":[{"count":53,"href":"https:\/\/www.bme.jhu.edu\/dolofflab\/wp-json\/wp\/v2\/pages\/1671\/revisions"}],"predecessor-version":[{"id":2644,"href":"https:\/\/www.bme.jhu.edu\/dolofflab\/wp-json\/wp\/v2\/pages\/1671\/revisions\/2644"}],"wp:attachment":[{"href":"https:\/\/www.bme.jhu.edu\/dolofflab\/wp-json\/wp\/v2\/media?parent=1671"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Select Publications<\/h2>\n\n\n\n
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![\"Complex-multi-cellular-signaling-in-biomaterial-response\"](\"https:\/\/www.bme.jhu.edu\/dolofflab\/wp-content\/uploads\/2018\/12\/Complex-multi-cellular-signaling-in-biomaterial-response-e1550678017751.jpg\")
<\/span>Latest News<\/h2>\n\n\n\n
New humanized mouse model for screening medical implant fibrosis and failure<\/h3>\n\n\n\n
Smoothing the Way to Better Breast Implants<\/h2>\n\n\n\n
Drug Crystals to prevent medical device fibrosis<\/h2>\n\n\n\n
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