Computational Medicine

PhD research in the field of Computational Medicine offers an extraordinary opportunity for graduate students to participate in clinically-oriented multi-disciplinary research projects with world-renowned faculty, where computational models of human disease and its treatment and prevention are used to develop novel personalized approaches to human health.

Computational Medicine is an emerging discipline devoted to the development of quantitative approaches for understanding the mechanisms, diagnosis and treatment of human disease through applications of mathematics, engineering and computational science. The core approach of Computational Medicine is to develop computational models of the molecular biology, physiology, and anatomy of disease, and apply these models to improve patient care.

Computational Medicine approaches can provide insight into and across many areas of biology, including genetics, genomics, molecular networks, cellular and tissue physiology, organ systems, and whole body pharmacology. Computational Medicine is distinct from Computational Biology in its focus on human health, disease, and treatment; translation to and application in the clinic is a near-term goal of all Computational Medicine research.

Applications of Computational Medicine are as broad as medicine itself, and include: identification of optimal drugs using associated genomic and proteomic biomarkers; discovery of image-based biomarkers for diagnosis and prognosis; design and dynamic adjustment of individualized non-drug therapies such as deep brain stimulation, cardiac stimulation, and cochlear implants; modeling and learning from patient EHR data to improve patient outcomes and efficiency of care; optimization of healthcare policy decisions by quantitative analysis; and more.

This field will continue to grow and to have a transformative impact on human health. Computational Medicine research at Johns Hopkins University is sub-divided into four key areas: Computational Molecular Medicine; Computational Physiological Medicine; Computational Anatomical Medicine; Computational Healthcare. Computational Medicine is one of the pillars of the University’s Strategic Initiative in Individualized Health.

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Computational Physiological Medicine

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Computational Anatomy

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Computational Molecular Medicine

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Computational Health Care

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