Research Areas
Bioinformatics and
Computational Biology
Biomedical research is being revolutionized by new technologies for
generating high throughput data. For
example, the mRNA counts contained
in gene microarrays provide a global
view of cellular activity by simultaneously recording the expression levels
of thousands of genes. Similarly, new
methods for measuring the expression
of proteins in cells and tissues and
mapping protein-protein interactions are
providing rich sources of information for
learning about disease mechanisms.
Research in bioinformatics in biomedical engineering and computational
medicine is currently focused on
representing and analyzing such data.
Bioinformatics/Computational
biology and computational medicine
research includes:
- Bioinformatic discovery of novel pharmaceutical targets, specifically in the area of vascular diseases and angiogenesis.
- Computational modeling and systems biology of angiogenesis.
- Computational modeling of how regulatory elements in DNA sequences are structured to control gene expression.
- Development of new machine learning methods for analysis of high throughput data.
- Large scale annotation of human genetic variation.
- Network modeling of protein-protein interactions.
- Predicting the impact of somatic variation in cancer genomes with molecular modeling and comparative genomics.
Faculty working in this areaJoel Bader Ph.D. Joseph Greenstein Ph.D. Feilim Mac Gabhann Ph.D. Aleksander Popel Ph.D. Sridevi Sarma Ph.D. Natalia Trayanova Ph.D. BME labs working in this areaBioinformatics and Computational Biology Lab Center for Cardiovascular Bioinformatics and Modeling Computational Cardiac Electrophysiology Laboratory Microvascular Development and Remodeling Laboratory Systems Biology Laboratory
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