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JHU Biomedical Engineering Primary Faculty

Sridevi V. Sarma, Ph.D.

Assistant Professor, Department of Biomedical Engineering
Institute for Computational Medicine

CSEB 217B

ssarma2 AT jhu.edu

Education

Ph.D., MIT, Electrical Engineering and Computer Science (EECS), Minor in Brain and Cognitive Sciences
S.M., MIT, Electrical Engineering and Computer Science (EECS)
B.S., Cornell University, Electrical Engineering

Research Interests

Developing control-oriented input-output models of basal ganglia nuclei (BG) and motor thalamus that describe how deep brain stimulation waveforms (input) influence neuronal activity (output) from cells in BG nuclei and motor thalamus for Parkinson's disease (PD) patients; developing models of how neuronal activity in BG and motor thalamus influence PD patient behavior such as tremor frequency, movement velocity, and reaction time.

Designing feedback control algorithms that measure neuronal activity from one or more BG nuclei in a PD patient with DBS, and in turn select the appropriate DBS inputs to one or more BG nuclei to generate normal-like neural activity and behavior. These control strategies will be based on the input-output models developed above.

Developing point process models of single neurons in the sub-thalamic nucleus (STN) of the BG in PD patients that describe spiking characteristics across space and time. This information can be used to determine whether the neurophysiology in different regions of the STN varies, and whether some regions are more pathological than others-which may ultimately guide optimal DBS electrode placement.

Selected Publications

Sarma, S.V., Dahleh, M.A., "Remote Control Over Noisy Communication Channels: A First-Order Example," IEEE Transactions on Automatic Control. February 2007

Sarma, S.V., Dahleh, M.A., Salapaka, S. "On Time-Varying Bit-Allocation Maintaining Stability and Performance: A Convex Parameterization," IEEE Transactions on Automatic Control. June 2008

Sarma, S.V., Dahleh, M.A. "Signal Reconstruction Under Finite-Rate Measurements: Finite-Horizon Control Applications," International Journal of Robust and Nonlinear Control. 2009

Sarma, S.V.; Cheng M.; Williams Z.; Hu R.; Brown E.N.; Eskandar E., "To Cue or Not to Cue-A Question for Parkinson's Patients," Nature Neuroscience.

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