Search bme.jhu.edu

JHU Biomedical Engineering Faculty

Joseph L. Greenstein, Ph.D.

Center for Cardiovascular Bioinformatics and Modeling
CSEB 316B
(410) 516-5425
jgreenst AT jhu.edu
Website

Education

Research Interests

Multi-scale mathematical modeling of the cardiac myocyte for the study of mechanisms underlying integrated cellular physiology in health and disease.

Modeling signaling pathways that regulate cardiac ionic currents and excitation-contraction coupling (e.g. beta-adrenergic, CaMKII, and nitric oxide mediated regulation of channel function).

Stochastic modeling of cardiac myocyte membrane ionic channels, Ca2+ ion diffusion, and excitation-contraction coupling within the cardiac dyad. Development of efficient biophysically based models (known as coupled models) of local control of Ca2+-induced Ca2+ release and regulation of CICR in the cardiac myocyte.

< Back to Primary Faculty page.