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JHU Biomedical Engineering Primary Faculty

Xingde Li, Ph.D.

Associate Professor, Biomedical Engineering
Associate Professor, Electrical and Computer Engineering, WSE

Biophotonics Imaging Science and Technology Laboratory
Ross 731B
(410) 955-0075
xingde AT jhu.edu

Education

BS, Physics, University of Science and Technology of China
PhD, physics and biomedical optics, University of Pennsylvania

Research Interests

Our research interest centers on development of translational biophotonics technologies that interface/bridge basic engineering research and medical diagnosis/therapy. The research involves integration of multiple disciplines, including (but not limited to) optics, electrical engineering, micro-nano technology, biology and clinical medicine. Applications of the technologies include detection of diseases at early, manageable stages; monitoring therapeutic effects and treatment outcomes; and guiding excisional biopsy and surgical interventions. The compact, robust and low cost nature of the technologies and their capability of performing noninvasive virtual “optical biopsy” make them potentially powerful for point of care and global health applications.

Technology focus:

• Optical Coherence Tomography (OCT)—noninvasive, real-time, high-resolution microanatomy and flow imaging;
• Fluorescence tomography based on diffuse photons (molecular imaging);
• Fiber-optic endomicroscopy for two-photon fluorescence, second harmonic generation and OCT imaging;
• Smart fluorescent polymeric nanocomplexes (micelles and nanoparticles) and bio-inert structured metallic nanocomplexes for translational molecular imaging, therapy and potentially controlled release.

Application focus:

• Systematic ultrahigh-resolution imaging of internal organs (e.g. human esophagus) for early detection of epithelial and subsquamous (hidden) lesions and monitoring treatment outcomes;
• Wound healing/tissue regeneration and influences/effects of stimuli;
• Fine optical needle imaging for image-guided biopsy;
• Non-destructive evaluation of materials and micro-devices.

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