Johns Hopkins Biomedical Engineering primary faculty

Xingde  Li, PhD

Xingde Li, PhD


Professor, Biomedical Engineering
Professor, Electrical and Computer Engineering, WSE
Fellow of OSA, SPIE and AIMBE

Office: Ross 731B
Lab: Laboratory of Biophotonics Imaging Technologies (BIT)


BS, Physics, University of Science and Technology of China (USTC), 1990
PhD, Physics and Biomedical Optics, University of Pennsylvania (UPenn), 1998

Research Interests

My research interest centers on development of cutting-edge and translational biophotonics technologies that interface and bridge basic engineering research and medical diagnosis and intervention. The research and training involves vertical integration of multiple disciplines, including (but not limited to) optics, electrical engineering, micro-nano technology, biology and clinical medicine. The ultimate goal of our research is to transform our capability of disease detection at early, manageable stages, monitoring therapeutic effects and treatment outcomes, and guiding interventions. The technologies also offer new opportunities for basic research in exploring new frontiers of disease mechanisms, brain function, bio-marker discovery and integrated diagnosis and therapy. Some specific research interests include:

  • Optical Coherence Tomography (OCT)
  • Multiphoton Endomicroscopy
  • Label-free Mass-spectrometry Imaging (MSI)
  • NIR Fluorescence Imaging
  • Functional Nanocapsules and Nanoparticles for Molecular Imaging
  • Noninvasive Cancer Detection, Infection and Inflammation Detection, Preterm Birth Assessment, Wound Healing Imaging and Surgical Guidance
  • In vivo Cellular Metabolism Imaging, Brain Function Imaging

Publications Search

From PubMed   |   Google Scholar Profile

Selected Publications

Liu XM, Chen YC, Cobb MJ, Kimmey MB, Li XD. “Rapid-scanning forward-imaging miniature endoscope for real-time optical coherence tomography,” Optics Letters 29(15):1763–1765 (2004).

Chen JY, Saeki F, Wiley BJ, Cang H, Cobb MJ, Li ZY, Au L, Zhang H, Kimmey MB, Li XD, Xia YN. “Immuno Gold Nanocages with Tailored Optical Properties for Targeted Photothermal Destruction of Cancer Cells," Nano Letters 5(3): 473–477 (2005).

Myaing MT, MacDonald DJ, Li XD. "Fiber-optic scanning two-photon fluorescence endoscope," Optics Letters 31(8):1076–1079 (2006).

Cobb MJ, Hwang JH, Upton MP, Chen YC, Oelschlager BK, Wood DK, Kimmey MB, Li XD. "Imaging of subsquamous Barrett's epithelium with ultrahigh-resolution optical coherence tomography: a histologic correlation study," Gastrointestinal Endoscopy 71(2):223–230 (2010) cover page.

Chen YP, Li XD.Near-infrared fluorescent probes with reversible response to thermal/pH modulation for optical molecular imaging,” BioMacromolecules12(12):4367–4372 (2011).

Zhang YY, Akins ML, Murari K, Xi JF, Li MJ, Luby-Phelps K, Mahendroo M, and Li XD.A compact fiber-optic SHG scanning endomicroscope and its application to visualize cervical remodeling during pregnancy,” Proceedings of National Academy of Sciences-USA 109(32):12878–12883 (2012).