JHU biomedical engineering primary faculty
Jordan J. Green, Ph.D.
Office: Smith 5017
Lab: Biomaterials and Drug Delivery Laboratory
Ph.D., Biological Engineering, MIT, 2007
B.S., Chemical Engineering, Biomedical Engineering, Carnegie Mellon University, 2003
Dr. Green's Biomaterials and Drug Delivery Laboratory is acutely interested in biomaterials, drug delivery, gene therapy, nanobiotechnology, and cell engineering. Research findings — and the technologies developed — are applied in the fields of ophthalmology, oncology, and regenerative medicine.
The lab works within the chemistry/biology/engineering interface to answer fundamental scientific questions, and to create innovative technologies and therapeutics that can directly benefit human health.
Current projects include:
- Development of safe and effective biodegradable nanoparticles for DNA and siRNA delivery to treat cancer
- Polymeric microparticle-based biological treatments for age-related macular degeneration
- Design of biomimetic artificial antigen presenting cells for immunobioengineering
- Enabling technologies for tissue engineering and regenerative medicine
Green, J.J. 2011 Rita Schaffer Lecture: Nanoparticles for Intracellular Nucleic Acid Delivery. Annals of Biomedical Engineering 2012, 40(7):1408–18.
Bhise, N.S., Shmueli, R.B., Gonzalez, J., Green, J.J. A novel assay for quantifying the number of plasmids encapsulated by polymer nanoparticles. Small 2012, 8(3):367–73.
Sunshine, J.C., Sunshine, S., Bhutto, I., Handa, J., Green, J.J. Poly(ß-amino ester)-Nanoparticle Mediated Transfection Of Retinal Pigment Epithelial Cells in vitro and in vivo. PLoS ONE 2012, 7(5): e37543.
Tzeng, S.Y., Hung B.P., Grayson, W.L., and Green, J.J. Cystamine-terminated poly(beta-amino ester)s for siRNA delivery to human mesenchymal stem cells and enhancement of osteogenic differentiation. Biomaterials 2012, 33(32): 8142–51.
Sunshine, J.C., Peng, D.Y., Green, J.J. Uptake and transfection with polymeric nanoparticles are dependent on polymer end-group structure, but largely independent of nanoparticle physical and chemical properties. Molecular Pharmaceutics 2012, 9(11): 3375–83.
Tzeng, S.Y. and Green, J.J. Subtle changes to polymer structure and degradation mechanism enable highly effective nanoparticles for siRNA and DNA delivery to human brain cancer. Advanced Healthcare Materials 2013, 2(3):468–80.