Jordan J. Green, Ph.D. Biomaterials and Drug Delivery Laboratory
Rangos 434
410-614-9113
green AT jhu.edu
Website EducationCarnegie Mellon University (2003), B.S., Biomedical Engineering and Chemical Engineering
Massachusetts Institute of Technology (2007), Ph.D., Biological Engineering
Research InterestsOur main research interests are in cellular engineering and nanobiotechnology, with special interests in biomaterials, controlled drug delivery, and gene therapy. The potential of gene therapy and genetic medicine to benefit human health is tremendous as almost all human diseases have a genetic component, from cancer to cardiovascular disease. Methods for drug and gene delivery that are both safe and effective have remained elusive. New insights into understanding and controlling the mechanisms of delivery are required to further advance the field. To accomplish this, our lab is developing a framework where biomaterials and nanoparticles can be rationally designed and computationally modeled. These same biomedical insights can also be used more broadly in the fields of regenerative medicine and nanomedicine. We work on the chemistry/biology/engineering interface to answer fundamental scientific questions and create innovative technologies and therapeutics that can directly benefit human health. Selected PublicationsGreen, J.J., Zhou, B.Y., Mitalipova, M.M., Beard, C., Langer, R., Jaenisch, R., Anderson, D.G. Nanoparticles for gene transfer to human embryonic stem cell colonies. Nano Letters. 2008, 8(10), 3126-3130.
Green, J.J., Langer, R., Anderson, D.G. A combinatorial polymer library approach yields insight into non-viral gene delivery. Accounts of Chemical Research. 2008, 41(6), 749-759.
Green, J.J., Zugates, G.T., Tedford, N.C., Huang, Y., Griffith, L.G., Lauffenburger, D.A., Sawicki, J.A., Langer, R., Anderson, D.G. Combinatorial modification of degradable polymers enables transfection of human cells comparable to adenovirus. Advanced Materials. 2007, 19(19), 2836-2842.
Green, J.J., Chiu, E., Leshchiner, E.S., Shi, J., Langer, R., Anderson, D.G. Electrostatic ligand coatings of nanoparticles enable ligand-specific gene delivery to human primary cells. Nano Letters. 2007, 7(4), 874-879.
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