JHU Biomedical Engineering Primary Faculty

Natalia Trayanova, Ph.D.

Murray B. Sachs Professor

Department of Biomedical Engineering and Institute for Computational Medicine

Computational Cardiology Laboratory
Hackerman Hall 216
410-516-4375
ntrayanova@jhu.edu
http://www.jhu.edu/trayanova/website/about.html

Education

PhD, Bulgarian Academy of Sciences (Sofia, Bulgaria), 1986
Post Doctoral Training, Biomedical Engineering, Duke University

Research Interests

The mission of the Computational Cardiology Lab is to develop and exploit cutting-edge computational tools to advance the understanding of the fundamental mechanisms that underlie rhythm and contractile disorders in the heart and to develop better strategies for prevention and treatment of these disorders. The research in Dr. Trayanova’s Computational Cardiology Lab centers around understanding the normal and pathological electrophysiological and electromechanical behavior of the heart using multi-scale simulation approaches that include biophysically-detailed representations of cellular and subcellular processes and image-based descriptions of the geometry and structure of the heart. Research projects focus on the mechanisms for cardiac arrhythmogenesis and cardiac electromechanical interactions. Importantly, a large number of projects are devoted to the improvement of the clinical therapies of defibrillation, infarct-related ventricular ablation, and cardiac resynchronization therapy using a personalized approach. Research in Dr. Trayanova’s laboratory is supported by grants from NIH, NSF, and the American Heart Association.

Selected Publications

Y. Hu, V. Gurev, J. Constantino, J.D. Bayer, N.Trayanova. Effects of Mechano-Electric Feed- back on Scroll Wave Stability in Human Ventricular Fibrillation. PLoS ONE, 8(4): e60287. doi:10.1371/journal.pone.0060287, 2013.

N.Trayanova, Computational Cardiology: The Heart of the Matter, ISRN Cardiology (Spotlight Article), vol. 2012, Article ID 269680, 15 pages, 2012. doi:10.5402/2012/269680, 2012.

R Winslow, N Trayanova, D Geman, M Miller, The Emerging Discipline of Computational Medicine, Science Translational Medicine, 4, 158rv11, 2012.

Moreno J, Zhu I, Yang P-C, Bankston J, Jeng M-T,Kang C, Wang L, Bayer J, Christini D, Trayanova N, Ripplinger C, Kass R, Clancy C. A computational model to predict antiarrhythmic drug effects on cardiac rhythms. Science Translational Medicine, 3, 98ra83, 2011.

N Trayanova, Whole-heart modeling: Applications to cardiac electrophysiology and electrome- chanics, Circ Res, 108:113-128, 2011

Vadakkumpadan F, Arevalo H, Prassl A, Chen J, Kickinger F, Kohl P, Plank G, Trayanova N. Image-based models of cardiac structure in health and disease. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2:489-506, 2010.

Jie X, Gurev V, Trayanova N. Mechanisms of mechanically induced spontaneous arrhythmias in acute regional ischemia, Circ Res, 106:185-192, 2010.

S.M. Narayan, J. Bayer, G. Lalani, N. Trayanova. Alternans in phase II of human ventricular action potentials predicts long-term outcomes: A mechanism linking failing myocardium with arrhythmias, JACC, 52:1782-1792, 2008.

T. Ashihara, J. Constantino, N. Trayanova. Tunnel propagation of postshock activations as a hypothesis for fibrillation induction and isoelectric window, Circ Res 102:737-745, 2008.

B. Rodrguez, L. Li, J. Eason, I. Efimov, N. Trayanova. Differences between left and right ventricular chamber geometry affect cardiac vulnerability to electric shocks. Circ. Res. 97:168- 175, 2005

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