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JHU Biomedical Engineering Primary Faculty

Jennifer H. Elisseeff, Ph.D.

Associate Professor of Biomedical Engineering

Tissue Engineering Laboratory
Clark Hall 106
(410) 516-4915
jhe AT bme.jhu.edu
Website

Education

Carnegie Mellon University (1994), B.S., Chemistry
Harvard-MIT Division of Health Sciences and Technology (1999), Ph.D., Biomedical Engineering

Research Interests

Biomaterials and Stem Cells for Tissue Engineering

Tissue and organ loss due to trauma, disease, and congenital abnormalities remains a significant clinical problem. Tissue engineering is a multidisciplinary field that aims to regenerate tissues and organs using the general approach of seeding cells on a scaffold. The scaffold serves many purposes including a three dimensional environment, soluble and insoluble cues to control cell function, maintenance of shape, and mechanical protection.

Biomaterials: We are examining hydrogels as a scaffold for tissue engineering. Advantages of hydrogels are the ability to encapsulate cells, high water content for nutrient and waste transport, and the ability to implant in a minimally invasive manner. Previous research focused on the development of photopolymerizing poly(ethylene oxide) for minimally invasive scaffold implantation and cartilage tissue engineering. The lab is currently focused on developing synthetic-biological hydrogels with highly controlled physical properties and biological function.

Stem Cells: The discovery of human embryonic stem cells has created the possibility to regenerate any tissue from a single, totipotent cell population. Currently, little is known about controlling the differentiation of stem cells. We are examining the potential of using biomaterials for stem cell differentiation and engineering mesenchymal tissues.

Selected Publications

Elisseeff, J., et al., Controlled-release of IGF-I and TGF-beta1 in a photopolymerizing hydrogel for cartilage tissue engineering. J Orthop Res, 2001. 19(6): p. 1098-104.

Elisseeff, J., et al., Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi- interpenetrating networks. J Biomed Mater Res, 2000. 51(2): p. 164-71.

Elisseeff, J., et al., Transdermal photopolymerization of poly(ethylene oxide)-based injectable hydrogels for tissue-engineered cartilage. Plast Reconstr Surg, 1999. 104(4): p. 1014-22.

Elisseeff, J., et al., Transdermal Photopolymerization for Minimally Invasive Implantation. Proc. Nat. Acad. Sc., USA, 1999. 96: p. 3104-3107.

Anseth, K.S., et al., In situ forming degradable networks and their application in tissue engineering and drug delivery. J Control Release, 2002. 78(1-3): p. 199-209.

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