JHU biomedical engineering primary faculty
Angelo H. All, M.D., M.B.A.
Assistant Professor
Office: Traylor 701 C
Lab: Spinal Cord Injury Laboratory
(410) 502-5393
hmn@jhu.edu
Education
M.B.A., Medical Services Management, Johns Hopkins University, 2008
M.D., Medicine, University of Verona, Italy, 1996
Research Interests
The focus of my research is on central nervous system injury, repair and regeneration. My spinal cord injury laboratory has pioneered the monitoring and quantitative analysis of multi-channel somatosensory and motor evoked potentials in order to assess the electrical integrity at various stages- both pre and post spinal cord injury. I also use different Imaging techniques to monitor anatomical changes in the injured spinal cord architectures at various time points. These images allow us to identify spared fibers and track the extent of secondary injury and determine the therapeutic benefit of the therapy. In addition, I have designed and implemented acute hypothermia treatment as well as chronic cell replacement therapy using oligodendrocyte precursor cells derived from human embryonic stem cells and iPS cells in a contusive model of spinal cord. I am interested in developing technologies leading up to clinical translation applications.
Selected Publications
Angelo H. All, Faith A. Bazley, Siddharth Gupta, Amir Pourmorteza, Nikta Pashai, Charles Hu, Candace Kerr. "Human embryonic stem cell-derived oligodendrocyte progenitors repair somatosensory pathways following contusive spinal cord injury." PLoS ONE 7(10): e47645. doi:10.1371/journal.pone.0047645M, Accepted 12 Sep 2012
Nikta Pashai, Haiping Hao, Angelo All, Siddharth Gupta, Raghothama Chaerkady, Alejandro De Los Angeles, John D. Gearhart and Candace L. Kerr, "Genome-Wide Profiling of Pluripotent Cells Reveals a Unique Molecular Signature of Human Embryonic Germ Cells." Submitted to PLoS ONE, April 2012. Accepted to PLoS ONE, May 2012. doi:10.3171/2012.1.SPINE11684
Faith A. Bazley, Charles Hu, Anil Maybhate, Amir Pourmorteza, Nikta Pashai, Nitish V. Thakor, Candace Kerr, Angelo H. All. "Electrophysiologal evaluation of sensory and motor pathways after incomplete unilateral spinal cord contusion.” Journal of Neurosurgery: Spine, 03 Feb 2012. doi:10.3171/2012.1.SPINE11684
Maybhate, Anil PhD; Hu, Charles BS; Bazley, Faith A. BS; Yu, Qilu PhD; Thakor, Nitish V. PhD; Kerr, Candace L. PhD; All, Angelo H. MD, MBA. "Potential long-term benefits of acute hypothermia after spinal cord injury: Assessments with somatosensory-evoked potentials." Critical Care Medicine, 13 Oct 2011 doi:10.1097/CCM.0b013e318232d97e. With an accompanying editorial by W. Dalton Dietrich, PhD, "Therapeutic hypothermia for acute severe spinal cord injury: Ready to start large clinical trials?" doi:10.1097/CCM.0b013e318236eacb
Chaerkady R, Letzen B, Renuse S, Sahasrabuddhe NA, Kumar P, All AH, Thakor NV, Delanghe B, Gearhart JD, Pandey A, Kerr CL. "Quantitative temporal proteomic analysis of human embryonic stem cell differentiation into oligodendrocyte progenitor cells." Proteomics, 11:1–14, 19 Jul 2011 doi:10.1002/pmic.20110010
Shrivats Iyer, Anil Maybhate, Alessandro Presacco, Angelo H. All, "Multi-limb acquisition of motor evoked potentials and its application in spinal cord injury," Journal of Neuroscience Methods, 193(2):210–216, 30 Nov 2010 doi:10.1016/j.jneumeth.2010.08.017
Angelo H. All, Gracee Agrawal, Piotr Walczak, Anil Maybhate, Jeff W.M. Bulte and Douglas A. Kerr. "Evoked potential and behavioral outcomes for experimental autoimmune encephalomyelitis in Lewis rats.” Neurological Sciences, 31(5):595, 28 May 2010 doi:10.1007/s10072-010-0329-y
Gracee Agrawal, Candace Kerr, Nitish V. Thakor, Angelo H. All. "Characterization of Graded MASCIS Contusion Spinal Cord Injury using Somatosensory Evoked Potentials." Spine Journal, 15 May 2010 doi:10.1097/BRS.0b013e3181be5fa7
Letzen BS, Liu C, Thakor NV, Gearhart JD, All AH, et al. "MicroRNA Expression Profiling of Oligodendrocyte Differentiation from Human Embryonic Stem Cells.” PLoS ONE, 5(5), 5 May 2010 doi:10.1371/journal.pone.0010480
Candace Kerr, Brian Letzen, Christine Hill, Gracee Agrawal, Nitish Thakor, Jared Sterneckert, John Gearhart and A. H. All. "Efficient differentiation of human embryonic stem cells into oligodendrocyte progenitors for application in a rat contusion model of spinal cord injury." International Journal of Neuroscience, 120:305–313, Apr 2010 doi:10.3109/00207450903585290
Walczak P., All A.H., Rumpal N., Gorelik M., Kim H., Maybhate A., Agrawal G., Campanelli J.T., Gilad A.A., Kerr D.A. "Human glial restricted progenitors survive, proliferate, and preserve electrophysiological function in rats with focal inflammatory spinal cord demyelination," Glia, Vol. 59, Iss. 3:499–510, Mar 2010 doi:10.1002/glia.21119
All, Angelo Homayoun. "Addressing the Inadequacies of the Current Healthcare Model with a Universal Healthcare System in the United States.” World Medical & Health Policy, 2(1):Article.20, 2010 doi:10.2202/1948-4682.103
Gracee Agrawal, Nitish V. Thakor and Angelo H. All. "Evoked Potential versus Behavior to Detect Minor Insult to Spinal Cord in Rat Model.” Journal of Clinical Neuroscience, 16(8):1052–1055, Aug 2009
Angelo All, Piotr Walczak, Gracee Agrawal, Christopher Lee, Nitish V. Thakor, Jeff W.M. Bulte and Douglas A. Kerr, "Effect of MOG sensitization on somatosensory evoked potential in Lewis rats.” Jour of the Neurological Sciences, 284:81–89, 6 May 2009 10.1016/j.jns.2009.04.025
Kartikeya Murari, Nan Li, Abhishek Rege, Xiaofeng Xia, Angelo All and Nitish Thakor. "Contrast-enhanced imaging of cerebral vasculature with laser speckle.” Applied Optics, Vol. 46, Iss. 22, August 2007
