Johns Hopkins Biomedical Engineering faculty
Patrick M. Boyle, PhD, PEng
Assistant Research ProfessorInstitute for Computational Medicine
Office: Hackerman Hall 217C
Lab: Computational Cardiology Laboratory
PhD, Biomedical Engineering, University of Calgary, 2011;
BSc, Computer Engineering, University of Calgary, 2005
The focus of my work is the development and application of sophisticated computer models of the human heart. Simulations executed using such models can be used to cultivate new knowledge about the underlying mechanisms of lethal cardiac arrhythmias and to develop novel strategies to treat these complex conditions. Patient-specific modeling of the human heart is now poised to address long-standing challenges in the field of cardiac electrophysiology, which is a truly thrilling prospect.
I am currently working on the development of simulation-based, custom-tailored atrial fibrillation ablation treatment plans based on each patient’s unique pattern of structural remodeling, as revealed by medical imaging.
I am also interested in using modeling to assess the feasibility of novel anti-arrhythmic devices based on emerging technologies, such as optogenetics. Simulations in this area can currently go far beyond what is possible in experimental and clinical research, meaning that insights from models will help guide and accelerate the engineering design process for the next generation of anti-arrhythmic devices.
A comprehensive multiscale framework for simulating optogenetics in the heart. Boyle PM, Williams JC, Ambrosi CM, Entcheva E, Trayanova NA. Nat Commun. 2013;4:2370.
Optogenetics-enabled dynamic modulation of action potential duration in atrial tissue: feasibility of a novel therapeutic approach. Karathanos TV, Boyle PM, Trayanova NA. Europace. 2014 Nov;16 Suppl 4:iv69–iv76.
Sodium current reduction unmasks a structure-dependent substrate for arrhythmogenesis in the normal ventricles.Boyle PM, Park CJ, Arevalo HJ, Vigmond EJ, Trayanova NA. PLoS One. 2014 Jan 28;9(1):e86947.
Transmural IK(ATP) heterogeneity as a determinant of activation rate gradient during early ventricular fibrillation: mechanistic insights from rabbit ventricular models. Boyle PM, Massé S, Nanthakumar K, Vigmond EJ. Heart Rhythm. 2013 Nov;10(11):1710–7.
"Beauty is a light in the heart": the transformative potential of optogenetics for clinical applications in cardiovascular medicine. Boyle PM, Karathanos TV, Trayanova NA. Trends Cardiovasc Med. 2015 Feb;25(2):73–81.
Fusion during entrainment of orthodromic reciprocating tachycardia is enhanced for basal pacing sites but diminished when pacing near Purkinje system end points. Boyle PM, Veenhuyzen GD, Vigmond EJ. Heart Rhythm. 2013 Mar;10(3):444–51.