JHU biomedical engineering faculty
Jian Du, Ph.D.
Office: Smith 5001M
Lab: Laboratory of Cell and Carbohydrate Engineering
Ph.D., Applied Chemistry, Chinese Academy of Sciences, 2005
B.S., Chemical Engineering, Liaoning University, China, 2000
The overall objective of my interests is to merge three lines of research that have independently shown promise for advancing tissue engineering endeavors — specifically biomaterial scaffolds, glycosylation engineering, and stem cell research.
- Exploiting the materials science to create 3D growth substrates with tunable chemistries on their surfaces to mimic the in vivo environment.
- Modulating the chemistry of the cell surface using metabolic oligosaccharide engineering method to form a complementary binding interface for cells to attach to scaffolds via a novel carbohydrate-based adhesion, and investigate how this adhesion effects cellular response of stem cells.
- Gaining a thorough understanding of how the sugar analogs used in metabolic oligosaccharide engineering elicit novel responses in stem cells, and developing a small molecule tools for stem cell therapies.
Du J, Che PL, Wang ZY, Aich U, and Yarema KJ. Designing a binding interface for control of cancer cell adhesion via 3D topography and metabolic oligosaccharide engineering. Biomaterials 2011, 32(23): 5427–5437.
Du J and Yarema KJ. Carbohydrate engineered cells for regenerative medicine. Advanced Drug Delivery Reviews 2010, 62(7–8):671–682.
Du J, Meledeo MA, Wang ZY, Khanna HS, and Yarema KJ. Metabolic glycoengineering: sialic acid and beyond. Glycobiology 2009, 19: 1382–1401.
Du J and Hsieh YL. Nanofibrous membranes from aqueous electrospinning of carboxymethyl chitosan. Nanotechnology 2008, 19: 125707.
Du J and Hsieh YL. PEGylation of chitosan for improved solubility and fiber formation via electrospinning. Cellulose 2007, 14: 543–552.
Du J, Dai J, and Liu JL. Novel pH-Sensitive polyelectrolyte carboxymethyl konjac glucomannan-chitosan beads as drug carriers. Reactive and Functional Polymers 2006, 66: 1055–1061.
Du J, Zhang S, Sun R, Zhang LF, Xiong CD, Peng YX. Novel polyelectrolyte complex carboxymethyl konjac glucomannan-chitosan nanoparticles as drug matrix: II. release of albumin in vitro. Journal of Biomedical Materials Research 2005,72B: 299–304.