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Targeted treatment for chronic sinusitis

May 6, 2016

Salient ENT

Salient ENT: The Hana Catheter system includes a novel, a low-profile nasal device and an external rinse bottle that interfaces with the internal catheter to increase fluid to the sinuses up to eightt-fold over the current standard.

A novel and innovative device to treat persistent and recurring sinus infections took the top award in the first-ever Johns Hopkins Student Healthcare Design Competition, held on the medical campus in early May and sponsored by the Johns Hopkins Center for Bioengineering Innovation and Design.

The competition, open to students from all Johns Hopkins divisions, was part of the Department of Biomedical Engineering’s Design Day. That annual event features presentations, posters, and prototypes of dozens of medical innovations developed over the year by student-clinician teams in BME’s Center for Bioengineering Innovation & Design.

Unlike the Johns Hopkins Business Plan Competition, which centers on business and market strategy, this challenge focused on the design and development of effective solutions to major health care problems. Forty-nine student teams from across the university submitted proposals, and 13 finalists competed in the May 3 event.

Attended by more than 300 researchers, clinicians, industry sponsors, and students, this year’s BME Design Day featured a keynote address by SynapDx CEO Stan Lapidus, a serial entrepreneur and inventor who founded and led Cytyc, Exact Sciences, and Helicos BioSciences, some inspired by the work of Johns Hopkins Medicine’s Bert Vogelstein, the Clayton Professor of Oncology and Pathology.

“Stan’s candid account of his experience was an inspiration,” says Youseph Yazdi, CBID’s executive director. “His innovations have saved millions of lives around the world, including here at Johns Hopkins. Today he gave a clear picture of the ups and downs, pivots, and perseverance necessary to be successful in health care innovation. I have no doubt there are several future Stans in that Design Day audience.”

The Healthcare Design Competition offered a $20,000 purse. First place, Salient ENT, received $4,000. Other top finishers included: Mercury Patch, a low-cost monitoring system for pressure sores (second place); and CricSpike, a hand-held device for emergency procedures on the battlefield to open a soldier’s blocked airway (third place).

“We’re thrilled to have received first place,” says Elizabeth Lebling, one of the inventors of Salient ENT, who graduates in May from the David E. Swirnow Master’s of Science in Bioengineering Innovation and Design program. “We’re starting conversations now with outside individuals who have experience translating these types of devices to the marketplace to help real patients.”

Roughly one in eight Americans suffer from persistent nasal sinus inflammation, Lebling says, and patients incur roughly $8.6 billion in annual surgical costs without adequate relief. Under the clinical direction of Andrew Lane, director of the Johns Hopkins Sinus Center, this design improves upon broad concepts developed by a 2012 CBID Team.

SalientENT

Salient ENT design team (l to r): Team leader Amal Alfroz Alam, Scott Stanley, Demetri Monovoukas, Emily Eggert, and Elizabeth Lebling.

Salient ENT has developed the “Hana Catheter” that is placed in a patient’s sinuses in a simple outpatient procedure. It can stay in place for up to 30 days, allowing the patient to connect an external rinse bottle to the catheter in order to deliver therapeutic fluids directly to inflamed tissue.

A 2012 CBID MSE team, under the direction of Lane, developed the broad concept, says CBID master’s student Scott Stanley, who plans to stay with Salient ENT through the startup phase. “We’ve advanced that concept and developed it into a functioning prototype. It’s been through benchtop and cadaveric testing, and our next step is working with a manufacturer to have it made to spec for animal and human testing.”

In addition to Lebling and Stanley, the team included CBID master’s students Amal Afroz Alam, Emily Eggert, and Demetri Monovoukas.

Other teams that received honorable mentions included: Organ Donation, a smartphone app to increase live organ donation; and Kubanda, a new breast cancer treatment device for low-resource settings. The Kubanda team also won the Linda Trinh Memorial Award at the Whiting School of Engineering’s Convocations Awards and Ceremony.

A team called Grup, which offered a mobile platform aimed at providing peer support and group therapy for those with depression and anxiety, received the CBID-Technology Innovation Center’s Digital Health Award.


— Mary Beth Regan

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